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GlossaryCyclin-dependent kinase (CDK)

enzyme that regulates cell cycle progression by partnering with cyclins

Cyclin-dependent kinases (CDKs) are a family of enzymes that play a crucial role in regulating the cell cycle, which is the process cells go through to divide and replicate. They work by partnering with proteins called cyclins to control the progression of cells through different phases of the cell cycle, ensuring that cells divide at the right time and maintain proper function.

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Prevention of Chemotherapy-Induced Alopecia in Rats by CDK Inhibitors

research Prevention of Chemotherapy-Induced Alopecia in Rats by CDK Inhibitors

153 citations , January 2001 in “Science”

Using CDK inhibitors on rats showed a reduction in chemotherapy-caused hair loss, but later experiments could not repeat these results.

research CDK4/6 Inhibition Mitigates Stem Cell Damage in a Novel Model for Taxane-Induced Alopecia

58 citations , September 2019 in “EMBO Molecular Medicine”

CDK4/6 inhibitors can protect hair cells from chemotherapy damage.

research CircRNA-1926 Promotes Differentiation of Goat SHF Stem Cells into Hair Follicle Lineage by miR-148a/b-3p/CDK19 Axis

16 citations , September 2020 in “Animals”

circRNA-1926 helps goat stem cells turn into hair follicles by affecting miR-148a/b-3p and CDK19.

CDK4/6 Plus Aromatase Inhibitor-Induced Alopecia in Breast Cancer Patients

research CDK4/6 Plus Aromatase Inhibitor-Induced Alopecia in Breast Cancer Patients

4 citations , May 2019 in “Journal of Clinical Oncology”

Some breast cancer treatments cause hair loss similar to male pattern baldness, which can be improved with minoxidil.

Hormone Receptor Positive, HER2 Negative Metastatic Breast Cancer: Impact of CDK4/6 Inhibitors on the Current Treatment Paradigm

research Hormone Receptor Positive, HER2 Negative Metastatic Breast Cancer: Impact of CDK4/6 Inhibitors on the Current Treatment Paradigm

4 citations , October 2018 in “Asia-Pacific Journal of Clinical Oncology”

CDK4/6 inhibitors have improved treatment outcomes for certain advanced breast cancer patients.

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