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GlossaryCDK inhibitors

block enzymes that regulate cell cycle progression

CDK inhibitors, or Cyclin-dependent kinase inhibitors, are a class of drugs that block the activity of enzymes known as cyclin-dependent kinases (CDKs). These enzymes play a crucial role in regulating the cell cycle, and their inhibition can halt the proliferation of cancer cells, making CDK inhibitors valuable in cancer treatment.

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research Establishment and Characterization of Immortalized Human Dermal Papilla Cells Expressing Human Papillomavirus 16 E6/E7

1 citations , November 2023 in “Journal of Microbiology and Biotechnology”

Immortalized human dermal papilla cells were created that grow better and can still help form hair.

research EGFR Signaling Is Required for Regenerative Proliferation in the Cochlea: Conservation in Birds and Mammals

53 citations , January 2012 in “Developmental Biology”

EGFR signaling is essential for ear cell regeneration in both birds and mammals.

research Cyclin-Dependent Kinase Inhibitors, P21waf1/Cip1 And P27kip1, Are Expressed Site- And Hair Cycle-Dependently In Rat Hair Follicles

9 citations , February 2001 in “Journal of Dermatological Science”

p21waf1/cip1 and p27kip1 help in hair follicle differentiation in rats.

Prevention of Chemotherapy-Induced Alopecia in Rats by CDK Inhibitors

research Prevention of Chemotherapy-Induced Alopecia in Rats by CDK Inhibitors

153 citations , January 2001 in “Science”

Using CDK inhibitors on rats showed a reduction in chemotherapy-caused hair loss, but later experiments could not repeat these results.

research Coordinate Expressions of Cyclin-Dependent Kinase Inhibitors and High Sulfur Protein in Human Hair Follicles

June 1996 in “Journal of Dermatological Science”

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