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GlossaryCalcineurin Inhibitors (Calcineurin Antagonists)

medications that suppress immune response by blocking calcineurin activity

Calcineurin inhibitors (CNIs) are a class of medications that suppress the immune system by blocking the activity of calcineurin, a protein involved in activating T-cells. They are commonly used to prevent organ transplant rejection and to treat autoimmune diseases. In dermatology, CNIs like tacrolimus and pimecrolimus are used topically to manage conditions such as atopic dermatitis and certain types of alopecia, as they help reduce inflammation and immune response in the skin.

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research Case Reports

6 citations , July 2004 in “JDDG Journal der Deutschen Dermatologischen Gesellschaft”

Frontal fibrosing alopecia in postmenopausal women can be managed with early treatment using corticosteroids to stop hair loss.

research Frontal Fibrosing Alopecia: Treatment with Oral Dutasteride and Topical Pimecrolimus

69 citations , August 2008 in “Journal of The European Academy of Dermatology and Venereology”

Oral dutasteride and topical pimecrolimus can safely and effectively treat Frontal Fibrosing Alopecia, leading to significant hair regrowth.

research Clinical Application of Nonantibiotic Macrolides for Inflammation-Driven Immune Dysfunction in Inflammatory Skin Diseases

22 citations , January 2012 in “Mediators of inflammation”

Nonantibiotic macrolides show promise for treating various inflammatory skin conditions.

research Skin Diseases Due to Endocrine Alterations

16 citations , January 2006 in “The Aging Male”

Hormone imbalances can cause skin diseases, and understanding these links is important for diagnosis and treatment.

Successful Treatment of Corticosteroid-Induced Rosacea-Like Dermatitis with Platelet-Rich Plasma Mesotherapy: Report of Seven Cases

research Successful Treatment of Corticosteroid-Induced Rosacea-Like Dermatitis with Platelet-Rich Plasma Mesotherapy: Report of Seven Cases

5 citations , February 2021 in “Dermatology and Therapy”

Platelet-rich plasma mesotherapy improved symptoms in patients with corticosteroid-induced rosacea-like dermatitis.

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community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Topical - Lantoprost .01%, MIN 10% DUT .05%, Hydrocortisone 1% Progrestron .025%

in Treatment 6 upvotes 3 months ago

A user was prescribed a topical treatment for hair loss including Latanoprost, Minoxidil, Dutasteride, Hydrocortisone, and Progesterone, after using an oral Minoxidil and Finasteride combo without significant results. Concerns were raised about the long-term use of hydrocortisone, with suggestions to consult a doctor regularly.