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research A phase 2a randomized, placebo-controlled study to evaluate the efficacy and safety of the oral Janus kinase inhibitors ritlecitinib and brepocitinib in alopecia areata: 24-week results

138 citations , March 2021 in “Journal of the American Academy of Dermatology”

This study found that treatment with ritlecitinib or brepocitinib was effective in improving scalp hair loss for patients with alopecia areata over 24 weeks compared to placebo.

research Breast implant illness: a topic in review

86 citations , January 2021 in “Gland Surgery”

This review article found no concrete evidence supporting the existence of "silicone implant illness" as a new syndrome, despite the association of various symptoms with breast implants which are considered safe according to current evidence.

research Revising the role of the androgen receptor in breast cancer

68 citations , April 2014 in “Journal of Molecular Endocrinology”

This review summarizes existing knowledge on androgen receptor activity in breast cancer and reports no new clinical findings, with emphasis on therapies targeting androgen signaling in specific BC subtypes.

research Vitamin D and androgen receptor-targeted therapy for triple-negative breast cancer

59 citations , April 2016 in “Breast Cancer Research and Treatment”

This study found that AR/VDR-targeted agonist hormone therapy can inhibit cell viability in HR2-av triple-negative breast cancer cell lines through multiple mechanisms and may enhance the effects of chemotherapy.

Matriptase Activation and Shedding with HAI-1 Induced by Steroid Sex Hormones in Human Prostate Cancer Cells, but Not in Breast Cancer Cells

research Matriptase activation and shedding with HAI-1 is induced by steroid sex hormones in human prostate cancer cells, but not in breast cancer cells

56 citations , February 2006 in “American journal of physiology. Cell physiology”

This study observed that in hormone-starved prostate cancer cells, the androgen 5alpha-dihydrotestosterone rapidly induces matriptase activation and shedding, which involves androgen receptor signaling and requires both transcription and protein synthesis.

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community Is breezula the last hope for new drugs?

1 upvotes 1 month ago

Breezula is seen as a potential future treatment for hair loss, but its release is uncertain and current data is limited. Other treatments like GT20026 and pyrilutamide are discussed, but skepticism remains about their effectiveness compared to established options like finasteride and minoxidil.

community Breezula is the final brick in the wall

36 upvotes 2 months ago

Breezula is discussed as a potential topical anti-androgen treatment for hair loss, with mixed opinions on its effectiveness and side effects compared to other treatments like finasteride, minoxidil, and RU58841. Some users express skepticism about its long-term efficacy and potential side effects, while others are hopeful for its approval and use in combination with existing treatments.

community Breaking news, new method to prevent hair loss

1496 upvotes 2 months ago

The conversation humorously discusses unconventional and satirical methods for preventing hair loss, such as using coffee and mayonnaise on the scalp. It mentions caffeine as a DHT blocker and jokes about various coffee-related treatments.

community Breezula Phase 3 Results enough for maintenance?

13 upvotes 4 months ago

Breezula shows promise in stabilizing hair loss and potentially promoting regrowth at the one-year mark, offering hope for those who can't tolerate 5AR inhibitors. Its local targeting of androgen receptors could be a significant advancement if it avoids systemic side effects.

community The Breezula 539% headline is doing a lot of heavy lifting right now.

16 upvotes 4 months ago

Breezula shows promising results for hair loss, with one trial showing a 539% improvement and another 168%, but lacks combination data with treatments like minoxidil or dutasteride. Its mechanism differs from finasteride, potentially offering fewer side effects by blocking receptors locally at the follicle.

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