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research Androgen Biosynthesis and Gene Defects

November 2014 in “Elsevier eBooks”

This article reviews the clinical and biochemical features of genetic mutations affecting dihydrotestosterone production and their potential role in male pseudo-hermaphroditism, but presents no new clinical results.

research Intracrine androgen biosynthesis, metabolism and action revisited

131 citations , September 2017 in “Molecular and Cellular Endocrinology”

This article discusses the role of androgens in metabolic and reproductive health and reports no new experimental results; the focus is on androgen receptor activation by testosterone and 5α-dihydrotestosterone.

research The Rise in Adrenal Androgen Biosynthesis: Adrenarche

173 citations , November 2004 in “Seminars in Reproductive Medicine”

This review discusses the physiological process of adrenarche, its impact on behavior and skeletal maturation, and its variability across sex and race, but reports no new clinical results.

research Epimedium brevicornum Maxim. Extract exhibits pigmentation by melanin biosynthesis and melanosome biogenesis/transfer

6 citations , September 2022 in “Frontiers in pharmacology”

In this study, Epimedii Folium extract was found to enhance melanin production and promote pigmentation through mechanisms involving the MAPK/ERK1/2 pathway in both in vitro and in vivo models.

research Staphylococcus aureus accessory gene regulator quorum-sensing system inhibits keratinocyte lipid enzymes and delays wound repair

1 citations , October 2025 in “Journal of Clinical Investigation”

This study found that Staphylococcus aureus delays wound healing by utilizing quorum sensing to impair lipid metabolism in keratinocytes, an effect not observed with commensal Staphylococcus, highlighting the impact of agr-dependent virulence factors in this process.

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community Would you continue to use Finasteride and Minoxidil once HMI 115 becomes available?

5 upvotes 2 years ago

The conversation discusses the potential use of HMI 115 for hair loss and whether it could replace or be used alongside finasteride, minoxidil, and RU58841. The user is experiencing scalp inflammation and continued hair shedding despite using finasteride for 8 years.

community Peptides that Stop Hair Loss? | In-depth Literature Review Video

76 upvotes 2 years ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

community Androsterone as a Neurosteroid Replacement Strategy for 5α-Reductase Inhibitor–Associated Sexual and Affective Dysfunction

in Research/Science 36 upvotes 2 months ago

Androsterone may help with sexual and affective dysfunction from finasteride by replacing disrupted neurosteroids without increasing androgenic side effects. Controlled testing is needed to confirm its effectiveness and safety.

community 28M experiencing thinning - first timer here, please help

in Treatments 370 upvotes 10 months ago

A 28-year-old male experiencing hair thinning is considering minoxidil and finasteride. Minoxidil helps regrow hair, while finasteride prevents further loss; both are usually lifelong treatments.

community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 3 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

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learn Melatonin

Hormone that regulates sleep, sold as a supplement

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