1 citations,
April 2021 in “Journal of Cardiovascular Pharmacology” Testosterone plays a big role in heart and nervous system damage caused by inflammation in male rats, suggesting that blocking testosterone production could help manage this condition.
April 2020 in “The FASEB Journal” Testosterone increases heart and blood pressure issues in rats with endotoxemia, and stopping testosterone production can reduce these problems.
1 citations,
November 2011 in “British journal of pharmacology” Enzymes are classified into six types and are essential for many biological processes, with only a few targeted by drugs.
8 citations,
December 2022 in “International journal of molecular sciences” Mice without the enzyme HSD17B3 still produce normal testosterone, suggesting they have different ways to make it compared to humans.
46 citations,
January 2010 in “The journal of investigative dermatology/Journal of investigative dermatology” Mice lacking Insig proteins had hair growth problems due to cholesterol buildup, but this was fixed by the drug simvastatin.