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research Bioengineered skin substitutes: key elements and novel design for biomedical applications

22 citations , October 2012 in “International Wound Journal”

This review discusses recent advancements in engineering bioengineered skin substitutes and highlights ongoing challenges, emphasizing the need for improvements in replicating uninjured skin; it reports no new experimental results.

research Bioengineered Skin Intended as In Vitro Model for Pharmacosmetics, Skin Disease Study and Environmental Skin Impact Analysis

26 citations , October 2020 in “Biomedicines”

This review discusses the applications and potential of Bioengineered Artificial Skin Substitutes in cosmetics and pharmacology research, with no new clinical findings reported.

research Composite skin substitutes, 3D skin bioprinting and the “BioMask” concept in regenerating skin defects - review

1 citations , September 2024 in “Journal of Education Health and Sport”

This review evaluates the clinical use of composite dermal-epidermal skin substitutes, with a focus on advancements such as the "BioMask" for facial skin trauma, highlighting the potential of 3D bioprinting and bioengineered skin in improving wound treatment and reconstruction.

research 742 Augmentation of HGF signaling: Potential for enhancing hair follicle neogenesis and development in bioengineered skin

April 2016 in “Journal of Investigative Dermatology”

This study suggests that hepatocyte growth factor (HGF) may play a role in hair follicle neogenesis and that an HGF mimetic could enhance skin substitute development.

research Immunological challenges associated with artificial skin grafts: available solutions and stem cells in future design of synthetic skin

105 citations , December 2017 in “Journal of Biological Engineering”

This review discusses the challenges of skin graft acceptance and examines current strategies and alternatives for full-thickness skin replacement and repair, noting that immunological rejection remains a significant hurdle.

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Community Join

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community Why hasn’t anyone made a "DHT sponge" biologic yet???

in Research/Science 45 upvotes 10 months ago

The conversation discusses the potential for developing a biologic "DHT sponge" to neutralize DHT in the bloodstream as a treatment for hair loss, suggesting it could be more targeted and have fewer side effects than current treatments like finasteride and dutasteride. Concerns include the complexity, cost, and potential side effects of such a treatment, as well as skepticism about its feasibility and market interest.

community We already know how to permanently fix hair loss. The science is done. The only thing missing is the funding to run one experiment.

in Technology 613 upvotes 4 months ago

A permanent hair loss solution could involve reprogramming hair follicles to resist DHT using mRNA and siRNA. However, high costs, safety concerns, and the pharmaceutical industry's preference for ongoing treatments over one-time cures are major obstacles, with finasteride and minoxidil remaining standard treatments.

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Learn

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learn Follistatin

glycoprotein that inhibits TGF-β and promotes hair growth by antagonizing activin

learn Beta Polypeptide

learn Thymosin Beta 4

learn Stem Cell Factor

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Clinics

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Experts

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36
SMP Specialist
Noelle Skin
Nice, France

Noelle Skin