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Did you mean Peripheral Benzodiazepine Receptor?

GlossaryTranslocator Protein (Peripheral Benzodiazepine Receptor)

protein on mitochondria involved in cholesterol transport and stress response

The Translocator Protein (TSPO), formerly known as the Peripheral Benzodiazepine Receptor (PBR), is a protein found on the outer membrane of mitochondria, the energy-producing structures in cells. It plays a crucial role in transporting cholesterol into mitochondria, which is essential for the production of steroid hormones. TSPO is also involved in cellular stress responses and inflammation, making it a target for research in various medical fields, including neurology and oncology.

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research Participation of GABAA, GABAB Receptors and Neurosteroids in Toluene-Induced Hypothermia: Evidence of Concentration-Dependent Differences in the Mechanism of Action

17 citations , October 2012 in “European Journal of Pharmacology”

Toluene lowers body temperature through different mechanisms depending on the concentration.

Production of 5α-Reduced Neurosteroids Is Developmentally Regulated and Shapes GABA A Miniature IPSCs in Lamina II of the Spinal Cord

research Production of 5α-Reduced Neurosteroids Is Developmentally Regulated and Shapes GABA A Miniature IPSCs in Lamina II of the Spinal Cord

88 citations , January 2004 in “Journal of Neuroscience”

Neurosteroids regulate synaptic inhibition in the spinal cord and may help manage spinal pain.

Midazolam Inhibits Hippocampal Long-Term Potentiation and Learning Through Dual Central and Peripheral Benzodiazepine Receptor Activation and Neurosteroidogenesis

research Midazolam Inhibits Hippocampal Long-Term Potentiation and Learning Through Dual Central and Peripheral Benzodiazepine Receptor Activation and Neurosteroidogenesis

97 citations , December 2010 in “Journal of Neuroscience”

Midazolam impairs learning and memory by increasing neurosteroids through specific receptor activation.

research Involvement of Neurosteroids in the Anxiolytic-Like Effects of AC-5216 in Mice

66 citations , January 2008 in “Pharmacology Biochemistry and Behavior”

AC-5216 reduces anxiety in mice through neurosteroids affecting GABAA receptors.

research Role of Neurosteroids in the Anticonvulsant Activity of Midazolam

28 citations , October 2011 in “British Journal of Pharmacology”

Midazolam's seizure prevention is partly due to increased neurosteroid production.

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community I quit Oral Finasterise over a year ago and here's what I've found

in Finasteride/Dutasteride 52 upvotes 3 months ago

The user quit oral finasteride over a year ago, experienced improvements in brain fog and erectile dysfunction after quitting smoking and porn, and plans to try dutasteride. Another user shared their experience with finasteride, mentioning panic attacks and anxiety, and managed symptoms through lifestyle changes like meditation and exercise.

community Do it yourself topical Fin and Min solution works

in Progress Pictures 119 upvotes 6 months ago

A homemade topical solution of finasteride and minoxidil effectively stopped hair shedding and promoted regrowth without side effects. Users shared experiences and discussed different concentrations and application methods.

community Completely defeated after trying so hard with topical finasteride.

in Finasteride/Dutasteride 24 upvotes 3 years ago

A user who has tried multiple treatments for hair loss, including oral and topical finasteride and liposomal finasteride, but experienced severe side effects in each case; the user is considering trying RU58841 or aromatise inhibitors as alternatives.

community 23M Couldn’t go bald for fear of my Girlfriend leaving me.

in Is this regrowth? 1090 upvotes 7 months ago

A 23-year-old man uses a topical spray with minoxidil, finasteride, and tretinoin for hair loss, experiencing improved hair growth but occasional heart palpitations. He worries his girlfriend might leave him if he goes bald, but commenters advise that if she would leave over hair loss, she isn't worth it.

community Possible Finasteride ban happening soon

in Finasteride/Dutasteride 165 upvotes 1 year ago

Concerns about a potential finasteride ban in the EU, possibly affecting the US, are discussed. Users doubt a ban, citing its widespread use and suggest alternatives like minoxidil and dutasteride.

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