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GlossaryTranslocator Protein (Peripheral Benzodiazepine Receptor)

protein on mitochondria involved in cholesterol transport and stress response

The Translocator Protein (TSPO), formerly known as the Peripheral Benzodiazepine Receptor (PBR), is a protein found on the outer membrane of mitochondria, the energy-producing structures in cells. It plays a crucial role in transporting cholesterol into mitochondria, which is essential for the production of steroid hormones. TSPO is also involved in cellular stress responses and inflammation, making it a target for research in various medical fields, including neurology and oncology.

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research Midazolam Inhibits Hippocampal Long-Term Potentiation and Learning Through Dual Central and Peripheral Benzodiazepine Receptor Activation and Neurosteroidogenesis

97 citations , December 2010 in “Journal of Neuroscience”

Midazolam impairs learning and memory by increasing neurosteroids through specific receptor activation.

research Midazolam Ameliorates the Behavioral Deficits of a Rat Posttraumatic Stress Disorder Model Through Dual 18 kDa Translocator Protein and Central Benzodiazepine Receptor and Neurosteroidogenesis

56 citations , July 2014 in “PLoS ONE”

Midazolam reduces PTSD-like behavior in rats by acting on specific brain receptors.

research Participation of GABAA, GABAB Receptors and Neurosteroids in Toluene-Induced Hypothermia: Evidence of Concentration-Dependent Differences in the Mechanism of Action

17 citations , October 2012 in “European Journal of Pharmacology”

Toluene lowers body temperature through different mechanisms depending on the concentration.

research RY-023, an Inverse Agonist at Alpha5 GABAA Receptors: The Influence on Spatial Memory and Spontaneous Locomotor Activity

August 2008 in “European Neuropsychopharmacology”

RY-023, a specific drug, can improve early stage memory learning without affecting general activity in rats, but it's less effective for later learning stages and doesn't impact memory recall.

research Involvement of Neurosteroids in the Anxiolytic-Like Effects of AC-5216 in Mice

66 citations , January 2008 in “Pharmacology Biochemistry and Behavior”

AC-5216 reduces anxiety in mice through neurosteroids affecting GABAA receptors.

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community I quit Oral Finasterise over a year ago and here's what I've found

in Finasteride/Dutasteride 52 upvotes 3 weeks ago

The user quit oral finasteride over a year ago, experienced improvements in brain fog and erectile dysfunction after quitting smoking and porn, and plans to try dutasteride. Another user shared their experience with finasteride, mentioning panic attacks and anxiety, and managed symptoms through lifestyle changes like meditation and exercise.

community Do it yourself topical Fin and Min solution works

in Progress Pictures 119 upvotes 3 months ago

A homemade topical solution of finasteride and minoxidil effectively stopped hair shedding and promoted regrowth without side effects. Users shared experiences and discussed different concentrations and application methods.

community Completely defeated after trying so hard with topical finasteride.

in Finasteride/Dutasteride 24 upvotes 2 years ago

A user who has tried multiple treatments for hair loss, including oral and topical finasteride and liposomal finasteride, but experienced severe side effects in each case; the user is considering trying RU58841 or aromatise inhibitors as alternatives.

community 23M Couldn’t go bald for fear of my Girlfriend leaving me.

in Is this regrowth? 1096 upvotes 4 months ago

A 23-year-old man uses a topical spray with minoxidil, finasteride, and tretinoin for hair loss, experiencing improved hair growth but occasional heart palpitations. He worries his girlfriend might leave him if he goes bald, but commenters advise that if she would leave over hair loss, she isn't worth it.

community Possible Finasteride ban happening soon

in Finasteride/Dutasteride 165 upvotes 9 months ago

Concerns about a potential finasteride ban in the EU, possibly affecting the US, are discussed. Users doubt a ban, citing its widespread use and suggest alternatives like minoxidil and dutasteride.

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