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GlossaryAzathioprine

immunosuppressive drug used to treat autoimmune diseases and alopecia

Azathioprine, also known by brand names such as Imuran, is an immunosuppressive medication commonly used to prevent organ rejection in transplant patients and to treat autoimmune conditions like rheumatoid arthritis and certain types of alopecia. It works by inhibiting the proliferation of immune cells, thereby reducing the immune system's activity and preventing it from attacking the body's own tissues.

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research Severe Thiopurine-Induced Myelotoxicity and Hair Loss in Japanese Patients with NUDT15 Gene Variant: A Retrospective Case-Control Study

April 2018 in “Journal of Investigative Dermatology”

Screening for the NUDT15 gene variant can prevent severe side effects from thiopurine drugs in East-Asian people.

research A Case Report of Thrombotic Thrombocytopenic Purpura Associated with Systemic Lupus Erythematosus: Overlapping Features

6 citations , January 2014 in “American Journal of Medical Case Reports”

Early diagnosis, intensive therapy, and careful follow-up are crucial for managing overlapping TTP and SLE.

research Management of Alopecia Areata

May 2018

Alopecia Areata is treated with drugs and therapies to reduce inflammation and immune response.

research Severe Alopecia Caused by Azathioprine in Systemic Lupus Erythematosus

July 2025 in “PubMed”

Azathioprine can cause severe hair loss and low white blood cell count in lupus patients.

research Azathioprine-Induced Agranulocytosis and Severe Alopecia After Kidney Transplantation Associated With a NUDT15 Polymorphism: A Case Report

6 citations , April 2018 in “Transplantation proceedings”

A woman experienced severe side effects from a drug due to a specific genetic variation, suggesting genetic testing could prevent such risks.

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community Not everyone should immediately go on Fin if they are starting to bald

in Finasteride/Dutasteride 21 upvotes 2 years ago

The conversation suggests that people should consult a dermatologist to understand their type of hair loss before starting treatments like finasteride or dutasteride, especially if they have autoimmune issues or low DHT. Some participants believe in starting treatment like finasteride immediately if hair loss is due to DHT, while others recommend ruling out other causes and considering minoxidil first, especially for younger individuals.