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GlossaryAzathioprine

immunosuppressive drug used to treat autoimmune diseases and alopecia

Azathioprine, also known by brand names such as Imuran, is an immunosuppressive medication commonly used to prevent organ rejection in transplant patients and to treat autoimmune conditions like rheumatoid arthritis and certain types of alopecia. It works by inhibiting the proliferation of immune cells, thereby reducing the immune system's activity and preventing it from attacking the body's own tissues.

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research Severe Thiopurine-Induced Myelotoxicity and Hair Loss in Japanese Patients with NUDT15 Gene Variant: A Retrospective Case-Control Study

April 2018 in “Journal of Investigative Dermatology”

Screening for the NUDT15 gene variant can prevent severe side effects from thiopurine drugs in East-Asian people.

research A Case Report of Thrombotic Thrombocytopenic Purpura Associated with Systemic Lupus Erythematosus: Overlapping Features

6 citations, January 2014 in “American Journal of Medical Case Reports”

Early diagnosis, intensive therapy, and careful follow-up are crucial for managing overlapping TTP and SLE.

research Efficacy and Tolerability of Azathioprine for Neuromyelitis Optica Spectrum Disorder: A Systematic Review and Meta-Analysis

54 citations, May 2019 in “Multiple Sclerosis and Related Disorders”

Azathioprine can help with relapses and disability in NMOSD but has more side effects and needs more research.

research Azathioprine

42 citations, January 1998 in “BioDrugs”

Azathioprine's effectiveness and safety require careful monitoring and more research, especially regarding its use with corticosteroids and the role of TPMT status in patients.

research Adverse Events Associated with Azathioprine Treatment in Korean Pediatric Inflammatory Bowel Disease Patients

16 citations, January 2013 in “Pediatric Gastroenterology Hepatology & Nutrition”

Azathioprine caused side effects in over half of the Korean pediatric inflammatory bowel disease patients, requiring close monitoring.

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