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research Degradation of Hair Surface: Importance of 18-MEA and Epicuticle

25 citations , May 2019 in “Cosmetics”

This paper reviews the surface degradation of hair and describes how combining 18-MEA with specific surfactants can maintain hydrophobicity on bleached and weathered hair surfaces.

research Extracellular Vesicles in Facial Aesthetics: A Review

8 citations , June 2022 in “International Journal of Molecular Sciences”

This review discusses the potential of extracellular vesicles for facial aesthetic applications, including scar reduction and skin rejuvenation, but reports no new clinical results; further research into production and mechanisms is needed.

research Cosmeceutical and Dermatological Potential of Olive Mill Wastewater: A Sustainable and Eco-Friendly Source of Natural Ingredients

4 citations , July 2025 in “Cosmetics”

This review discusses the potential of olive mill wastewater as a valuable source of dermatological ingredients, highlighting its antioxidant and anti-inflammatory properties, but reports no new clinical results.

research The role of androgen and androgen receptor in skin-related disorders

124 citations , July 2012 in “Archives of Dermatological Research”

This review discusses the roles of androgens and androgen receptors in skin-related disorders and suggests that targeting androgen receptors may be a more effective treatment strategy.

research Discovery of an Androgen Receptor Degrader Featuring a Pyridazinyl Glutarimide CRBN-Binding Motif for Transdermal Treatment of Androgenetic Alopecia

May 2026 in “Journal of Medicinal Chemistry”

In this study, the authors developed a novel PROTAC named dAR-6–1, which demonstrated superior hair regeneration in an AGA mouse model compared to minoxidil, highlighting its promise as a therapy due to potent AR degradation and excellent skin permeability.

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community AH-001 another topical AR degrader beside GT20029, completed Phase I

8 upvotes 10 months ago

AH-001 is a new topical treatment designed to degrade androgen receptors, targeting the root cause of androgenetic alopecia without the side effects of oral treatments like finasteride. It has shown a strong safety profile and good local tolerability in early trials.

community SCUBE3 and GT20029 could be the closet thing to a cure: Hair Follicle Regeneration and Protection Against DHT

14 upvotes 3 years ago

SCUBE3 and GT20029 are potential treatments for hair loss, with SCUBE3 stimulating hair growth and GT20029 protecting against DHT. A combined approach using SCUBE3, finasteride or dutasteride, and later GT20029 could provide a comprehensive treatment for androgenetic alopecia.

community Research: Minoxidil grows hair by suppressing androgen activity (DHT) in hair follicles.

43 upvotes 6 years ago

Minoxidil may suppress androgen activity in hair follicles, potentially aiding in hair growth and prostate cancer treatment. Users discuss the effectiveness of minoxidil and finasteride for hair maintenance and regrowth, with some preferring topical applications over oral due to safety concerns.

community What new hair-loss treatments actually look exciting right now (Oct 2025)

171 upvotes 11 months ago

New hair loss treatments include Breezula, PP405, ET-02, KX-826, GT20029, VDPHL01, and CosmeRNA, with some showing promise in reactivating stem cells and reversing greying. Breezula and VDPHL01 are highlighted as potential add-ons or alternatives to current treatments like finasteride and minoxidil.

community GT20029: How It Works for Hair Loss - Hair Loss “Cure”

38 upvotes 7 months ago

GT20029 is a potential treatment for androgenetic alopecia, addressing the root cause by targeting androgen receptors, unlike Minoxidil or Finasteride. It is seen as a preventative measure rather than a regrowth agent, with hopes for market release soon.

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learn GT20029

research compound made to degrade androgen receptors in scalp

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37
Hair Transplant Surgeon
Dr. Shashikiran AR, MD, MBBS, FRGHS
Mysuru, Karnataka, India

Dr. Shashikiran AR, MD, MBBS, FRGHS