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Antiandrogen Drugs Lower Serum Prostate-Specific Antigen Levels in Hirsute Subjects: Evidence That Serum PSA Is a Marker of Androgen Action in Women

research Antiandrogen Drugs Lower Serum Prostate-Specific Antigen (PSA) Levels in Hirsute Subjects: Evidence That Serum PSA Is a Marker of Androgen Action in Women¹

16 citations , January 2000 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

This study found that serum PSA levels are higher in hirsute women and can be significantly reduced by antiandrogen treatment, suggesting PSA as a marker of androgen action in females.

research Antiandrogenic drugs, a therapeutic option for frontal fibrosing alopecia patients

10 citations , March 2016 in “Journal of The American Academy of Dermatology”

This review discusses the potential usefulness and safety profile of oral antiandrogens for treating frontal fibrosing alopecia, noting possible benefits but acknowledges that finasteride's efficacy remains uncertain.

research Anti-Androgen Drugs in the Treatment of Obsessive-Compulsive Disorder: A Systematic Review

1 citations , December 2019 in “Current Medicinal Chemistry”

This study found that anti-androgens may reduce OCD symptoms, but the evidence is of low quality and further large, randomized trials are needed.

research Bicalutamide: A potential new oral antiandrogenic drug for female pattern hair loss

8 citations , April 2020 in “Journal of The American Academy of Dermatology”

This article discusses the potential of oral bicalutamide as a promising treatment for female pattern hair loss and reports no new clinical results.

research Structure of human steroid 5α-reductase 2 with the anti-androgen drug finasteride

30 citations , October 2020 in “Nature Communications”

This study provides the first crystal structure of the human SRD5A2 enzyme, revealing key insights into its function and inhibition which may aid future drug development.

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Community Join

5 / 666 results

community 22M, dutasteride + spironolactone miracle, I was losing 400-500 hairs everyday, after starting the drugs I completely stopped shedding and experienced crazy regrowth in just 3-4 months

61 upvotes 1 year ago

A 22-year-old male experienced significant hair regrowth and stopped shedding after using dutasteride and spironolactone for 3-4 months. Spironolactone is discussed as an antiandrogen, typically used for women or transitioning individuals, and not commonly recommended for men due to potential side effects.

community here is why isotretinoin might cause hair loss and maybe why dupa happens.

in Research/Science 7 upvotes 3 years ago

Isotretinoin may cause hair loss by increasing DHT through a precursor androgen, DHEAS. Treatments like topical antiandrogens (RU58841, pyrilutamide) and drugs increasing PPAR-y expression (pioglitazone) might prevent this hair loss.

community Anti-androgen use causing testicular pain?

in Finasteride/Dutasteride 5 upvotes 1 year ago

Switching from topical finasteride to oral Dutasteride and using Fluridil caused persistent testicular discomfort. The discomfort did not subside after stopping Fluridil, raising concerns about Dutasteride's role.

community Drug restored full hair in 23% and over 80% of hair in 55% in 6 months

240 upvotes 3 weeks ago

An arthritis drug restored significant hair in people with alopecia areata, but it is not effective for male pattern baldness. The drug, Upadacitinib, has serious side effects and is expensive.

community Even if the new drugs succeed, how are we gonna apply so many topicals?

11 upvotes 4 months ago

New hair loss treatments like GT20029, Clascoterone, and PP405 are being discussed, with concerns about how to apply multiple topicals alongside existing treatments like minoxidil and finasteride. Suggestions include creating a routine, mixing treatments, or minimizing redundancy in treatment stacks.

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Learn

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learn Bicalutamide

a nonsteroidal anti-androgen, most commonly used orally for women

Can bicalutamide stop DHT from shrinking your hair follicles? Bicalutamide blocks androgens at the receptor rather than lowering DHT, and some dermatologists prescribe it off-label for women with pattern hair loss. The published evidence is retrospective case series and one small pilot study, with no randomized trial; it is a prescription drug that requires liver monitoring and is contraindicated in pregnancy.

learn Minoxidil

An essential vasodilator with some anti-androgenic effects

learn Dutasteride

Heavy duty finasteride that comes with higher risks

learn Overview

learn GT20029

What is GT20029 and how does it work as a topical anti-androgen for hair loss? GT20029 is a topical anti-androgen that degrades androgen receptors to combat hair loss.

learn Pyrilutamide

Is pyrilutamide a safer alternative to oral antiandrogens like finasteride? Pyrilutamide may be a safer topical alternative to oral antiandrogens like finasteride.

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Clinics

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14
Hair Loss Treatments
Dr Joydeep Roy's Skin Clinic, New S.S.Medicos, (near Cachar high school), Malugram/ Drugs Corner, itkhola near Cachar CollegeSilchar, Assam · IN

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