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Glossary Androstenedione

steroid hormone precursor to testosterone and estrogen

Androstenedione, often referred to as Andro, is a steroid hormone that serves as a precursor in the biosynthesis of testosterone and estrogen. It is produced in the adrenal glands, ovaries, and testes, and plays a crucial role in the development of secondary sexual characteristics and reproductive function. Elevated levels of androstenedione can be associated with conditions like polycystic ovary syndrome (PCOS) and certain forms of adrenal hyperplasia.

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research Puberty in Boys: Correlation of Plasma Levels of Gonadotropins (LH, FSH), Androgens (Testosterone, Androstenedione, Dehydroepiandrosterone and Its Sulfate), Estrogens (Estrone and Estradiol) and Progestins (Progesterone and 17-Hydroxyprogesterone)

96 citations , September 1975 in “The Journal of Clinical Endocrinology & Metabolism”

In this study, significant elevations of DHA and testosterone were associated with pubic hair development and voice changes in boys during puberty.

research Clinical Usefulness of Plasma Androstanediol Glucuronide Measurements in Women with Idiopathic Hirsutism*

66 citations , October 1987 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

This study found that serum 3 alpha-diol G levels in women with idiopathic hirsutism correlated well with their clinical response to treatment, suggesting its usefulness in evaluating treatment outcomes.

research 6 Peripheral androgens and the role of androstanediol glucuronide

57 citations , May 1986 in “Clinics in endocrinology and metabolism”

This review found that women with idiopathic hirsutism may have increased 5α-reductase activity, as indicated by elevated levels of a dihydrotestosterone-reduced metabolite, but more research is needed to confirm its clinical relevance as a biomarker.

research Elevated serum androstenedione is associated with a more severe phenotype in women with polycystic ovary syndrome (PCOS)

28 citations , April 2014 in “Hormones”

This study found that increased serum A4A levels were associated with more severe polycystic ovary syndrome phenotypes and could be a useful marker for biochemical hyperandrogenemia.

The Influence of Obesity on Androstenedione to Testosterone Ratio in Women with Polycystic Ovary Syndrome and Hyperandrogenemia

research The influence of obesity on Androstenedione to Testosterone ratio in women with polycystic ovary syndrome (PCOS) and hyperandrogenemia

15 citations , October 2011 in “Gynecological Endocrinology”

This study found that obesity in PCOS women with biochemical hyperandrogenemia lowers androstenedione levels and increases the testosterone to androstenedione ratio, but this was not observed in women with clinical hyperandrogenemia or in controls.

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community Why is my hair falling out for 4 years?

1 upvotes 1 year ago

A 22-year-old woman has experienced hair loss for four years, with normal test results except for testosterone and androstenedione. She is not using treatments like Minoxidil or finasteride and is unsure of the cause, with suggestions pointing to female pattern hair loss or chronic Telogen Effluvium possibly due to stress.

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