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    Glossary Androstenedione

    steroid hormone precursor to testosterone and estrogen

    Androstenedione, often referred to as Andro, is a steroid hormone that serves as a precursor in the biosynthesis of testosterone and estrogen. It is produced in the adrenal glands, ovaries, and testes, and plays a crucial role in the development of secondary sexual characteristics and reproductive function. Elevated levels of androstenedione can be associated with conditions like polycystic ovary syndrome (PCOS) and certain forms of adrenal hyperplasia.

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    1. Puberty in Boys: Correlation of Plasma Levels of Gonadotropins (LH, FSH), Androgens (Testosterone, Androstenedione, Dehydroepiandrosterone and Its Sulfate), Estrogens (Estrone and Estradiol) and Progestins (Progesterone and 17-Hydroxyprogesterone) The Journal of Clinical Endocrinology & Metabolism · 1975 · 96 citations
    2. Clinical Usefulness of Plasma Androstanediol Glucuronide Measurements in Women with Idiopathic Hirsutism* 1987 · 66 citations
    3. 6 Peripheral androgens and the role of androstanediol glucuronide Clinics in endocrinology and metabolism · 1986 · 57 citations
    4. Elevated serum androstenedione is associated with a more severe phenotype in women with polycystic ovary syndrome (PCOS) Hormones · 2014 · 28 citations
    5. The influence of obesity on Androstenedione to Testosterone ratio in women with polycystic ovary syndrome (PCOS) and hyperandrogenemia Gynecological Endocrinology · 2011 · 15 citations
    6. Scalp hair 17‐hydroxyprogesterone and androstenedione as a long‐term therapy monitoring tool in congenital adrenal hyperplasia Clinical Endocrinology · 2016 · 9 citations
    7. Is 3α, 17β-androstanediol-glucuronide a diagnostic marker in women with androgenic manifestations? Gynecological Endocrinology · 1992 · 3 citations
    8. Androstenedione Strength and Conditioning Journal · 1999
    9. Androstanediolglucuronide: A parameter for peripheral androgen activity before and during therapy with cyproterone acetate European journal of endocrinology · 1991 · 8 citations
    10. Testosterone modulation of seizure susceptibility is mediated by neurosteroids 3α-androstanediol and 17β-estradiol Neuroscience · 2004 · 136 citations
    11. A high-performance liquid chromatography–tandem mass spectrometry assay of the androgenic neurosteroid 3α-androstanediol (5α-androstane-3α,17β-diol) in plasma Steroids · 2005 · 19 citations
    12. A Model for Predicting Polycystic Ovary Syndrome Using Serum AMH, Menstrual Cycle Length, Body Mass Index and Serum Androstenedione in Chinese Reproductive Aged Population: A Retrospective Cohort Study Frontiers in Endocrinology · 2022 · 5 citations
    13. 3α-androstanediol, but not testosterone, attenuates age-related decrements in cognitive, anxiety, and depressive behavior of male rats Frontiers in Aging Neuroscience · 2010 · 63 citations
    14. Serum 3α-androstanediol-glucuronide is decreased in nonhirsute women with acne vulgaris Fertility and Sterility · 1996 · 10 citations
    15. Effects of non-contingent cocaine on 3alpha-androstanediol. I. Disruption of male sexual behavior Physiology & Behavior · 2019 · 4 citations
    16. Correlation of Serum 3<i>α</i>-Androstanediol Glucuronide with Acne and Chest Hair Density in Men The Journal of Clinical Endocrinology & Metabolism · 1988 · 51 citations
    17. Female androgenic alopecia. The 3 alpha,17 beta-androstanediol glucuronide/sex hormone binding globulin ratio as a possible marker for female pattern baldness Archives of Dermatology · 1986 · 13 citations
    18. Evidence of Increased 3‐Alpha‐Androstanediol Glucuronide in Female Pattern Alopecia: A Cross‐Sectional Observational Study Evaluating Ovarian, Adrenal, and Peripheral Androgens International Journal of Dermatology · 2026
    19. 3 alpha, 17 beta-androstanediol glucuronide in plasma. A marker of androgen action in idiopathic hirsutism. 1982 · 179 citations
    20. Sebocytes are the Key Regulators of Androgen Homeostasis in Human Skin 2001 · 196 citations
    21. 5α-Reductase activity in the human hair follicle concentrates in the dermal papilla Archives of Dermatological Research · 1998 · 41 citations
    22. PLASMA C19 STEROID SULPHATE LEVELS AND INDICES OF ANDROGEN BIOAVAILABILITY IN FEMALE PATTERN ANDROGENIC ALOPECIA Clinical Endocrinology · 1990 · 32 citations
    23. Metabolism of androgens by isolated human beard hair follicles Steroids · 1971 · 31 citations
    24. Human androgenic steroids affect growth of dermatophytes <i>in vitro</i> Mycoses · 1996 · 24 citations
    25. Metabolism of androgens by isolated human hair follicles Journal of Steroid Biochemistry · 1972 · 22 citations
    26. Androgen regulation of a specific gene in hamster flank organs Archives of dermatological research · 1991 · 12 citations
    27. [Hirsutism]. PubMed · 1976
    28. 24-Hydroxycholesterol suppresses steroid 5α-reductase-catalyzed conversion in human glioblastoma cell lines: A novel link between brain cholesterol homeostasis and androgen metabolism Neurochemistry International · 2026
    29. Insulin administration alters gonadal steroid metabolism independent of changes in gonadotropin secretion in insulin-resistant women with the polycystic ovary syndrome. Journal of Clinical Investigation · 1989 · 202 citations
    30. SERUM STEROIDS AND PITUITARY HORMONES IN FEMALE PUBERTY: A PARTLY LONGITUDINAL STUDY Clinical Endocrinology · 1980 · 186 citations