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research Androgen Receptor–Mediated Paracrine Signaling Induces Regression of Blood Vessels in the Dermal Papilla in Androgenetic Alopecia

6 citations , January 2022 in “Journal of Investigative Dermatology”

This study found that androgen receptor signaling is linked to blood vessel regression in the dermal papilla of balding scalp, contributing to hair follicle miniaturization in androgenetic alopecia.

research Anti-Hair Loss Potential of Perilla Seed Extracts: In Vitro Molecular Insights from Supercritical Fluid Extraction

July 2025 in “Foods”

In this study, perilla seed extract obtained through supercritical fluid extraction was found to promote hair follicle cell proliferation and downregulate key genes linked to androgenetic alopecia, showing potential as a natural treatment for hair loss in vitro.

research The genetically programmed hair growth cycle and alopecia: what is there to know?

3 citations , June 2006 in “Expert Review of Dermatology”

This review discusses recent advances in hair follicle research, highlighting therapeutic and cosmetic applications, but reports no new study results.

research Induction of transforming growth factor-beta 1 by androgen is mediated by reactive oxygen species in hair follicle dermal papilla cells

56 citations , September 2013 in “Journal of Biochemistry and Molecular Biology”

This study observed that androgen treatment increased ROS production and TGF-β1 secretion in rat hair follicle dermal papilla cells, suggesting that the androgen-induced TGF-β1 is mediated by ROS.

research Integrative analysis reveals ncRNA-mediated molecular regulatory network driving secondary hair follicle regression in cashmere goats

50 citations , March 2018 in “BMC Genomics”

This study expands knowledge of non-coding RNAs in goats and other mammals, enhancing understanding of their roles in hair follicle growth and regression.

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community Serious question, is there nothing that can be done if Dutasteride doesn’t help to stop my hair loss?

60 upvotes 4 years ago

A 25 year old male who has been using finasteride and dutasteride for two years to treat his hair loss, with no success. Other treatments such as oral minoxidil, topical anti-androgens, RU58841, latanoprost, topical estrogen, CB 03 01, microneedling, keto 2% shampoo, vitamin D, Omega 3, B vitamins and probiotics were discussed.

community Prolactin the Cause of Hair Loss? ABS-201 the Cure?

29 upvotes 2 months ago

Prolactin may contribute to hair loss, but targeting its receptor won't cure androgenetic alopecia. ABS-201 could be a useful alternative or adjuvant therapy, similar to JAK inhibitors, but not more effective than HMI-115.

community M25: Getting way too many DMs, so let’s do this here! AMA about Male Pattern Baldness, Hair Loss, and Products (100% Science-Backed )

1951 upvotes 5 months ago

Finasteride, dutasteride, and minoxidil are discussed as treatments for male pattern baldness. Finasteride and dutasteride are effective DHT blockers, while minoxidil is necessary for regrowth but must be used consistently.

community The Real Cause Of Androgenetic Alopecia

675 upvotes 1 year ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community Day 1 vs Day 168 (today) of defeating the norwood reaper

1528 upvotes 2 years ago

The user achieved significant hair regrowth using topical 5% minoxidil and oral 1mg finasteride daily, especially around the temples. They experienced minimal side effects, with initial difficulty maintaining erections that resolved after a few weeks.

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learn Neem Oil

Oil from the neem tree, used in traditional remedies

learn Finasteride

Popular 5-alpha reductase inhibitor that lowers DHT, taken as a pill or used topically

Does hair strand thickness decrease in men with androgenic alopecia? Can finasteride help restore it? Androgenic alopecia thins hair strands by miniaturizing follicles. The pivotal finasteride trials (1,553 men, 1 mg/day, two years) report increased hair counts and improved assessed appearance, but they measured density, not the diameter of individual strands, so the effect on thickness itself is not established.

learn Alfatradiol

Alfatradiol: What does a form of estrogen have to do with hair loss in men? Alfatradiol (17α-estradiol) is a topical hormone sold without prescription in German pharmacies, licensed there for mild androgenetic alopecia, and not FDA-approved. The controlled trial evidence is in women, where hair density and thickness stayed nearly unchanged over 6 months while minoxidil improved them (the trial had no placebo group); no comparable placebo-controlled trial in men appears to have been published.

learn Bicalutamide

Can bicalutamide stop DHT from shrinking your hair follicles? Bicalutamide blocks androgens at the receptor rather than lowering DHT, and some dermatologists prescribe it off-label for women with pattern hair loss, although its US label says it should not be used in women. The one randomised trial (74 women, 2025) found it added no benefit to oral minoxidil, and the drug needs liver monitoring because its label warns of severe and fatal liver injury; it is contraindicated in pregnancy.

learn KY19382

Experimental compound that activates hair-growth signals, tested only in animals

learn Nanoxidil

learn GT20029

Experimental topical drug designed to break down androgen receptors

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SMP Specialist
Hairo Fallas
Newark, NJ, United States

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Hairo Fallas