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Glossary Androgen Activity

effects of male sex hormones on body tissues

Androgen activity refers to the effects that androgens, which are male sex hormones like testosterone, have on the body. These hormones bind to specific receptors in various tissues, influencing characteristics such as hair growth, muscle mass, and the development of male secondary sexual characteristics. In the context of hair, increased androgen activity can lead to conditions like androgenic alopecia, commonly known as male or female pattern baldness.

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Research

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research Prenatal and adult androgen activities in alcohol dependence

63 citations , April 2017 in “Acta psychiatrica Scandinavica”

This study observed that higher prenatal androgen loads were associated with more severe alcohol dependence in male patients and linked to behaviors of pregnant women that may influence their children’s androgen exposure.

research Intratumoral De Novo Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors

402 citations , August 2011 in “Cancer research”

This study found that castration-resistant prostate cancers resistant to CYP17A1 inhibitors may still depend on steroids and could respond to therapies targeting de novo intratumoral steroid synthesis.

research Identification of Anabolic Selective Androgen Receptor Modulators with Reduced Activities in Reproductive Tissues and Sebaceous Glands

36 citations , October 2009 in “Journal of biological chemistry/The Journal of biological chemistry”

This study reports that TFM-4AS-1, a selective androgen receptor modulator, promoted bone and muscle growth with reduced effects on reproductive organs in ovariectomized rats.

research Guava (Psidium guajava L.) Leaf Extract as Bioactive Substances for Anti-Androgen and Antioxidant Activities

7 citations , December 2022 in “Plants”

This study suggests that guava leaf extract may inhibit hair loss by downregulating genes involved in androgen synthesis, potentially offering a natural alternative for treating androgenetic alopecia.

research The Expressions of Androgen Receptors and Estrogen Receptors in Bald and Non-bald Area of Androgenic Alopecia

1 citations , January 2002 in “Journal of Clinical Dermatology”

This study found that androgen receptors were more prevalent in bald areas compared to non-bald areas in individuals with androgenic alopecia, suggesting a link between increased local androgen activity and hair loss.

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community Minoxidil is NOT an Anti-androgen. No.

in Research/Science 43 upvotes 10 months ago

Minoxidil is not an anti-androgen; it is a growth stimulator and does not lower DHT like finasteride or dutasteride. Minoxidil can cause side effects like facial swelling and anxiety due to its vasodilator properties.

community Having androgen receptor density and sensitivity at wrong f*ing place

in Satire 7 upvotes 1 year ago

The conversation discusses hair loss treatments, focusing on the use of topical minoxidil, microneedling, finasteride, and dutasteride, while debating the role of testosterone and DHT in hair loss. It also touches on the potential liver health impacts of these treatments and the genetic sensitivity of hair follicles to androgens.

community Insulins impact on androgen levels

16 upvotes 4 years ago

Controlling insulin levels through intermittent fasting and a low glycemic diet may improve hair quality by reducing androgens. It's important to maintain proper nutrition, including electrolytes and protein, during fasting.

community Is there a topical androgen receptor blocker so we don't have to fuck with the enzyme and destroy our allopregnanolone, but go and hit the end target straight?

in Treatment 44 upvotes 2 years ago

The conversation discusses topical androgen receptor blockers for hair loss, mentioning Clascoterone, Pyrilutamide, GT20029, and RU58841. Ketoconazole's effectiveness and application methods are also debated.

community Study: There is 70x Higher Unconjugated DHT in Feces Compared To Blood Levels in Young Adults - Gut Microbiota Manages DHT Recycling and Metabolism

in Research/Science 194 upvotes 1 year ago

Gut microbiota significantly influences androgen metabolism, impacting hair loss treatments like finasteride. Probiotics, dietary changes, and fecal microbiota transplants may help manage DHT levels and improve hair health.

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Learn

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learn GT20029

What is GT20029 and how does it work as a topical anti-androgen for hair loss? GT20029 is an investigational topical androgen-receptor degrader. One 12-week Phase II trial in 180 Chinese men found two of four regimens beat placebo on hair count; it is not approved or available.

learn Spironolactone

Who is spironolactone used for in androgen-related hair thinning, and who should avoid it? Studies of spironolactone for hair loss are mostly in adult women; its use is off-label, it is avoided in pregnancy and generally not used in men, and the US label advises potassium checks (DailyMed, Aldactone).

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