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research Mechanism of action of androgen in hair follicles

25 citations , July 1994 in “Journal of dermatological science”

This study observed that testosterone metabolism and androgen receptor localization differ significantly across body sites, with beard hair follicles showing distinct characteristics compared to occipital scalp hair follicles.

research The Mechanism of Androgen Actions in PCOS Etiology

30 citations , August 2019 in “Medical Sciences”

This review summarizes evidence suggesting that excess androgens play a key role in the origins of polycystic ovary syndrome, highlighting opportunities for developing targeted treatments.

research Differences in the mechanisms of androgen action in hair follicles from women and men with androgenetic alopecia

2 citations , March 2000 in “CRC Press eBooks”

research Molecular mechanisms of androgen receptor functions

November 2007 in “Data Archiving and Networked Services (DANS)”

This thesis reviews the molecular mechanisms of androgen receptor functions, including receptor structure and interaction with other proteins, and reports no new experimental findings.

research MECHANISM OF ACTION OF AVICENNIA MARINA HEARTWOOD EXTRACT AND AVICEQUINONE C ON HUMAN DERMAL PAPILLA CELLS ISOLATED FROM ANDROGENIC ALOPECIA PATIENTS

January 2016

This study found that Avicennia marina extract and its active compound avicequinone C inhibit enzymes and receptors related to androgenic alopecia, potentially supporting hair growth in cultured dermal papilla cells.

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community Finasteride's impact on blood pressure - mechanism of action

4 upvotes 5 years ago

Finasteride may cause mild blood pressure-related side effects in less than 10% of users, unlike minoxidil, which has stronger effects. Alternatives like topical ketoconazole and dermarollers are suggested for those concerned about finasteride's side effects.

community Why Fin/Dut Isn't Working for You GPR133: a new hairloss mechanism + Steroid Hair Loss Deep Dive

6 upvotes 2 months ago

Hair loss may be linked to the GPR133 receptor, independent of the androgen receptor pathway. Treatments like finasteride, dutasteride, minoxidil, RU58841, and KX-826 show varying results, with hair loss persisting due to high testosterone and GPR133's role.

community GT20029 and PP405 the new fin and min that we been waiting for ?

36 upvotes 1 year ago

PP405 and GT20029 are new hair loss treatments with different mechanisms from traditional options like Minoxidil and Finasteride. PP405 targets hair follicle stem cells to reactivate growth, while GT20029 works as an androgen receptor deleter, both requiring ongoing use for effectiveness.

community Is there any new drug that looks promising ?

26 upvotes 2 years ago

The conversation discusses GT20029, a drug in Phase II trials that targets androgen receptors with minimal systemic effects, and TDM-105795, a growth stimulant with a different mechanism than minoxidil that may revive papilla stem cells. Both are potential new treatments for hair loss.

community A Technical Question About Pyrilutamide

in Research/Science 5 upvotes 3 years ago

Pyrilutamide is believed to be more effective than RU58841 and 1 mg finasteride in treating hair loss, with no systemic hormonal effects and the potential to block more than 31% of scalp DHT. It may also antagonize scalp testosterone due to its action as an androgen receptor antagonist.

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