research Exome-Wide Age-Of-Onset Analysis Reveals Exonic Variants In ERN1 And SPPL2C Associated With Alzheimer’s Disease
Researchers found two new genetic variants linked to Alzheimer's disease.
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5 / 1000+ results research Alzheimer Disease: What's New, What's True?
Alzheimer's Disease (AD) affects 55 million people globally and is characterized by brain changes such as amyloid beta and tau aggregation, neuroinflammation, and neuronal death. Despite FDA-approved antibody treatments targeting amyloid-beta, no effective treatment exists, particularly for women and ApoE4 carriers. AD is increasingly seen as a multifactorial disease with neuroinflammation and gut microbiome dysbiosis playing significant roles. Recent studies suggest that pro-inflammatory gut bacteria in prodromal AD are linked to reduced cerebral blood flow and cognitive dysfunction, while beneficial bacteria are associated with better brain health. These findings highlight the potential for novel diagnostic and therapeutic approaches targeting the gut microbiome and inflammation in AD.
research Increased Hair Polyamine Levels in Patients with Alzheimer's Disease
Alzheimer's patients have higher levels of certain chemicals in their hair.
research P4-276: A Case of Apparently Reversible Alzheimer's Disease
Effective sleep apnea treatment may reverse cognitive decline in Alzheimer's.
research An Examination of Alzheimer’s Disease and White Matter from 1981 to 2023: A Bibliometric and Visual Analysis
The U.S., China, and the U.K. lead Alzheimer's and white matter research.
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5 / 60 resultscommunity Oral minoxidl - Is this a medication that's generally safe to take for life? Like what I understand oral fin is? Also do studies show that in general or in a significant amount of more cases that results with oral minox + oral fin > oral fin in terms of long-term use(talkin 20+ years).
Oral minoxidil combined with finasteride can improve hair density, but long-term safety is uncertain due to potential side effects like heart and kidney issues. Users report mixed experiences, with some experiencing side effects and others finding it effective for hair maintenance.
community Am I balding? Should I just shave it off?(M86)
A user humorously questions if they should shave their head due to hair loss, mentioning Ronald Reagan's impressive hair genetics. Replies include jokes and comments about jealousy and distrust towards older individuals with full heads of hair.
community Federal Grant Cuts have impacted PP405 related research
Federal funding cuts have delayed PP405 research, affecting hair loss treatment progress, though clinical trials will continue. The discussion highlights PP405's potential compared to minoxidil and finasteride and stresses the importance of government-funded research.
community Why is Kevin Mann (Haircafe) Hated?
Hair loss treatments, including microneedling, minoxidil, finasteride and RU58841; the efficacy of these treatments; criticisms of Kevin Mann's content related to his selective data presentation and biases towards certain treatments; and other topics such as DHT being labeled a "trash hormone" and critiques of other hairloss YouTubers.
community 22 years since the last major development
The conversation discusses the lack of significant advancements in hair loss treatments since the introduction of finasteride 22 years ago, with many expressing frustration over the failure of new projects and skepticism about future developments. Some users mention hair transplants and other potential alternatives like Alfatradiol and Fluridil, but acknowledge finasteride's dominance in the market due to its effectiveness and affordability.