An Examination of Alzheimer’s Disease and White Matter from 1981 to 2023: A Bibliometric and Visual Analysis

This bibliometric and visual analysis of Alzheimer's Disease (AD) and white matter research from 1981 to 2023 reveals a significant increase in publications, particularly after 2009, due to the growing recognition of the link between AD and white matter changes. The study identifies 5,714 relevant articles, with the United States leading in research output, followed by China and the United Kingdom. Key research themes include the role of biomarkers and white matter alterations in AD, emphasizing the importance of early diagnostic markers. The study highlights the interdisciplinary nature of AD research and the need for continued collaboration to advance understanding and treatment strategies, despite limitations such as potential language bias and reliance on a single database.