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GlossaryAllopregnanolone

neurosteroid derived from progesterone that modulates brain activity

Allopregnanolone, also known as 3α-hydroxy-5α-pregnan-20-one, is a neurosteroid derived from progesterone. It plays a crucial role in modulating the brain's response to stress and anxiety by enhancing the activity of GABA, the primary inhibitory neurotransmitter. This compound is also being studied for its potential therapeutic effects in conditions like depression, anxiety disorders, and certain neurodegenerative diseases.

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Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients

research Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients

223 citations, December 2010 in “The Journal of Sexual Medicine”

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

research A Rapid Method for Obtaining Finasteride, a 5α-Reductase Inhibitor, from Commercial Tablets

14 citations, April 2002 in “Brain Research Protocols”

Quickly get finasteride from tablets using easy methods.

research The Impact of the 5α-Reductase Inhibitors on Male Sexual Function and Psychological Well-Being

1 citations, August 2015 in “Current Sexual Health Reports”

5α-reductase inhibitors can cause serious and possibly lasting sexual and psychological side effects.

Post-Finasteride Syndrome: When Will We Get the Courage to Fight the Dictating Pharma Industry Despite Awareness of Sexual, Neurological, and Metabolic Side Effects in Young Men for Over a Decade

research Post-Finasteride Syndrome: When Will We Get the Courage to Fight the Dictating Pharma Industry Despite Awareness of Sexual, Neurological, and Metabolic Side Effects in Young Men for Over a Decade

January 2020 in “Archives of urology”

Finasteride, a drug used for certain conditions, can cause serious side effects like sexual dysfunction, suicidal thoughts, and increased diabetes risk, and there's a need for more awareness and research about these effects.

5α-Reductase Inhibition Prevents the Luteal Phase Increase in Plasma Allopregnanolone Levels and Mitigates Symptoms in Women with Premenstrual Dysphoric Disorder

research 5α-Reductase Inhibition Prevents the Luteal Phase Increase in Plasma Allopregnanolone Levels and Mitigates Symptoms in Women with Premenstrual Dysphoric Disorder

110 citations, August 2015 in “Neuropsychopharmacology”

High-dose dutasteride reduces PMDD symptoms by stabilizing neurosteroid levels.

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community PCOS female who posted before; saw Endo today. prescribed spironolactone and minox 5%

in Update 1 upvotes 1 year ago

PCOS female visited doctor for hair loss concerns, prescribed spironolactone and minox 5%. Doctor advised against finasteride or dutasteride, user considering self-medication with dutasteride.

community Breezula CB-03-01

in Treatment 10 upvotes 5 years ago

The conversation is about a potential new hair loss treatment called Breezula CB-03-01. Users are discussing updates on its development and sharing personal experiences with making or using it.

community DHT and 5AR respect post, it's importance within the brain

in Research/Science 111 upvotes 1 year ago

The conversation discusses whether to use finasteride for hair loss, considering its role in inhibiting DHT and 5AR, which can affect brain function and mood. Some users report anxiety and depression from finasteride, while others do not experience these side effects and emphasize the importance of DHT for brain and prostate health.

community Why use Finasteride instead of Dutasteride?

in Finasteride/Dutasteride 39 upvotes 1 year ago

People are discussing why some choose finasteride over dutasteride for hair loss, noting that while dutasteride is more effective, it's also more expensive, less researched, and potentially has more side effects. Some users shared personal experiences with side effects from both drugs, and others mentioned that finasteride is FDA approved for hair loss, while dutasteride is not, except in Japan.

community How many of you have significant others?

in Shaved/buzzed 105 upvotes 1 year ago

The conversation revolves around the experiences of different individuals with hair loss treatments like Minoxidil, Finasteride, and RU58841. The discussion includes various perspectives on the effects of these treatments, the importance of hair for self-esteem and attractiveness, and the influence of significant others on the decision to use or stop using these treatments.

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