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GlossaryAllopregnanolone

neurosteroid derived from progesterone that modulates brain activity

Allopregnanolone, also known as 3α-hydroxy-5α-pregnan-20-one, is a neurosteroid derived from progesterone. It plays a crucial role in modulating the brain's response to stress and anxiety by enhancing the activity of GABA, the primary inhibitory neurotransmitter. This compound is also being studied for its potential therapeutic effects in conditions like depression, anxiety disorders, and certain neurodegenerative diseases.

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Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients

research Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients

223 citations , December 2010 in “The Journal of Sexual Medicine”

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

Epoxy Fatty Acids and Inhibition of the Soluble Epoxide Hydrolase Selectively Modulate GABA Mediated Neurotransmission to Delay Onset of Seizures

research Epoxy Fatty Acids and Inhibition of the Soluble Epoxide Hydrolase Selectively Modulate GABA Mediated Neurotransmission to Delay Onset of Seizures

60 citations , December 2013 in “PLoS ONE”

EETs can delay seizures by affecting GABA activity, offering potential new treatments for seizures.

research A Rapid Method for Obtaining Finasteride, a 5α-Reductase Inhibitor, from Commercial Tablets

14 citations , April 2002 in “Brain Research Protocols”

Quickly get finasteride from tablets using easy methods.

research The Impact of the 5α-Reductase Inhibitors on Male Sexual Function and Psychological Well-Being

1 citations , August 2015 in “Current Sexual Health Reports”

5α-reductase inhibitors can cause serious and possibly lasting sexual and psychological side effects.

research Altered Hormone and Bioactive Lipid Plasma Profile in Rodent Models of Polycystic Ovarian Syndrome Revealed by Targeted Mass Spectrometry

March 2025 in “Journal of Endocrinology and Metabolism”

Rodent models of PCOS show some hormone changes similar to humans, but also have key differences.

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community To the people who had hairloss on .5mg dutasteride and increased it to 2.5mg, did that do the trick for you or do you still have hairloss?

in Finasteride/Dutasteride 10 upvotes 3 weeks ago

Increasing dutasteride from 0.5mg to 2.5mg may not significantly reduce hair loss and can cause side effects like sleep disturbances and brain fog. Many users find 0.5mg effective enough, while some switch to topical finasteride due to side effects.

community 4 1/2 months of Dut and Oral Min Update

in Update 377 upvotes 1 month ago

Significant hair regrowth was achieved after 4.5 months using 0.5 mg Dutasteride and 5 mg oral Minoxidil. Tips on obtaining prescriptions and discussions on effectiveness and side effects were also shared.

community I quit Oral Finasterise over a year ago and here's what I've found

in Finasteride/Dutasteride 52 upvotes 3 months ago

The user quit oral finasteride over a year ago, experienced improvements in brain fog and erectile dysfunction after quitting smoking and porn, and plans to try dutasteride. Another user shared their experience with finasteride, mentioning panic attacks and anxiety, and managed symptoms through lifestyle changes like meditation and exercise.

community PCOS female who posted before; saw Endo today. prescribed spironolactone and minox 5%

in Update 1 upvotes 2 years ago

PCOS female visited doctor for hair loss concerns, prescribed spironolactone and minox 5%. Doctor advised against finasteride or dutasteride, user considering self-medication with dutasteride.

community Breezula CB-03-01

in Treatment 11 upvotes 6 years ago

The conversation is about a potential new hair loss treatment called Breezula CB-03-01. Users are discussing updates on its development and sharing personal experiences with making or using it.

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