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research Efficacy and safety of the oral Janus kinase 3/tyrosine kinase expressed in hepatocellular carcinoma family kinase inhibitor ritlecitinib over 24 months: integrated analysis of the ALLEGRO phase IIb/III and long-term phase III clinical studies in alopecia areata

23 citations , October 2024 in “British Journal of Dermatology”

In this study, ritlecitinib showed sustained effectiveness and a favorable safety profile in treating alopecia areata in patients aged 12 and older over 24 months, with improvements observed in hair and eyebrow regrowth and patient satisfaction.

research Patterns of clinical response in patients with alopecia areata treated with ritlecitinib in the ALLEGRO clinical development programme

13 citations , February 2025 in “Journal of the European Academy of Dermatology and Venereology”

Ritlecitinib shows promise for treating alopecia areata, especially with early and extended treatment.

research Sustained hair regrowth with continued ritlecitinib treatment through week 48 in patients with alopecia areata with or without early target responses: Post hoc analysis of the ALLEGRO phase 2b/3 trial

7 citations , October 2024 in “Journal of the American Academy of Dermatology”

This source reported that patients who initially responded to ritlecitinib treatment showed sustained hair regrowth through week 48, with up to one-third of those not meeting target efficacy at week 24 also achieving a response with continued treatment.

research Long-Term Efficacy of Ritlecitinib up to Month 24 From the ALLEGRO Phase 2b/3 and Long-Term Phase 3 Clinical Studies in Alopecia Areata

6 citations , March 2024 in “SKIN The Journal of Cutaneous Medicine”

In this ongoing phase 3 study, ritlecitinib demonstrated sustained efficacy up to 24 months in patients aged 12 or older with alopecia areata, showing increased response rates with or without an initial loading dose and supporting its long-term use.

research UVB-induced depletion of donor-derived dendritic cells prevents allograft rejection of immune-privileged hair follicles in humanized mice

6 citations , November 2018 in “American journal of transplantation”

This study reported that using UVB preirradiation and anti-CD154 antibody treatment in a humanized mouse model prolonged hair follicle allograft survival and reduced immune cell infiltration without needing generalized immunosuppression.

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community Addressing the fake allegations on my 200 day dut progress

in Chat 33 upvotes 11 months ago

The conversation is about a user defending their hair loss progress photos against accusations of being fake, explaining changes in hair color and texture due to dyeing and straightening. The user shares their treatment timeline, using dutasteride and minoxidil, and addresses side effects and skepticism from others.

community Anyone interested in starting dutasteride religion?

in Chat 34 upvotes 1 year ago

A humorous discussion about forming a "religion" around dutasteride for hair loss treatment, with members jokingly pledging allegiance and sharing experiences. Some users mention switching from finasteride to dutasteride, noting differences in side effects and effectiveness.

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