70 citations
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April 2016 in “Experimental Dermatology” In this study, oral tofacitinib treatment led to significant hair regrowth and changes in skin and blood biomarkers in a patient with alopecia areata.
130 citations
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February 2018 in “Journal of Investigative Dermatology” This study found that tofacitinib led to ≥50% hair regrowth in eight out of twelve patients with moderate to severe alopecia areata, suggesting a potential benefit for using JAK inhibitors in treating this condition.
31 citations
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December 1991 in “Annals of the New York Academy of Sciences” This study found that distinct keratin profiles enabled the evaluation of epithelial differentiation in human hair follicles, with mesenchymal cells playing a critical role in epidermoid differentiation of follicular cells.
December 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” This study observed that extracellular matrix scaffold membranes performed less effectively in wound healing for aged mice compared to younger ones, with senescent SPP1+ macrophages potentially hindering epidermal and fibroblast repair abilities.
135 citations
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November 1987 in “Differentiation” This study found that cultured outer root sheath cells from human hair follicles expressed a keratin profile similar to their in vivo environment, indicating environmental influence on keratin expression.
