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GlossaryAgouti Signaling Protein

protein influencing hair color by inhibiting melanocortin 1 receptor

Agouti Signaling Protein (ASIP) is a protein that plays a crucial role in determining hair color in mammals. It works by inhibiting the action of the melanocortin 1 receptor (MC1R), which leads to the production of yellow or red pigments (pheomelanin) instead of black or brown pigments (eumelanin). This protein is also involved in various biological processes, including energy metabolism and obesity.

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research Bone morphogenetic protein (BMP) signaling controls hair pigmentation by means of cross-talk with the melanocortin receptor-1 pathway

70 citations , December 2004 in “Proceedings of the National Academy of Sciences”

BMP signaling affects hair color by interacting with the MC-1R pathway.

research Sox2 in the Dermal Papilla Regulates Hair Follicle Pigmentation

9 citations , July 2022 in “Cell reports”

Sox2 controls hair color by affecting pigment production in hair follicles.

research Premature Graying as a Consequence of Compromised Antioxidant Activity in Hair Bulb Melanocytes and Their Precursors

46 citations , April 2014 in “PLOS ONE”

Gray hair may be caused by lower antioxidant activity in hair cells.

research Functionally Distinct Melanocyte Populations Revealed by Reconstitution of Hair Follicles in Mice

10 citations , November 2010 in “Pigment Cell & Melanoma Research”

Only skin melanocytes, not other types, can color hair in mice.

research The Biology of Hair Growth

10 citations , January 2009 in “Elsevier eBooks”

Hair growth is influenced by hormones and goes through different phases; androgens can both promote and inhibit hair growth depending on the body area.

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