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    Glossary Agouti Signaling Protein

    protein influencing hair color by inhibiting melanocortin 1 receptor

    Agouti Signaling Protein (ASIP) is a protein that plays a crucial role in determining hair color in mammals. It works by inhibiting the action of the melanocortin 1 receptor (MC1R), which leads to the production of yellow or red pigments (pheomelanin) instead of black or brown pigments (eumelanin). This protein is also involved in various biological processes, including energy metabolism and obesity.

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    Research 10 of 182

    1. Bone morphogenetic protein (BMP) signaling controls hair pigmentation by means of cross-talk with the melanocortin receptor-1 pathway Proceedings of the National Academy of Sciences · 2004 · 70 citations
    2. Comparative genome analyses reveal the unique genetic composition and selection signals underlying the phenotypic characteristics of three Chinese domestic goat breeds Genetics selection evolution · 2019 · 30 citations
    3. The Agouti Gene in Obesity: Central and Peripheral Mechanisms, and Therapeutic Implications 2001
    4. Down-regulation of Melanocortin Receptor Signaling Mediated by the Amino Terminus of Agouti Protein in XenopusMelanophores Journal of Biological Chemistry · 1999 · 43 citations
    5. Agouti and Agouti-related Protein: Analogies and Contrasts Journal of Biological Chemistry · 2000 · 135 citations
    6. An Intrinsic Oscillation of Gene Networks Inside Hair Follicle Stem Cells: An Additional Layer That Can Modulate Hair Stem Cell Activities Frontiers in Cell and Developmental Biology · 2020 · 23 citations
    7. The Role of gp91phox and the Effect of Tranexamic Acid Administration on Hair Color in Mice International Journal of Molecular Sciences · 2019 · 2 citations
    8. Resequencing Analyses Revealed Genetic Diversity and Selection Signatures during Rabbit Breeding and Improvement Genes · 2024
    9. Deciphering principles of morphogenesis from temporal and spatial patterns on the integument Developmental Dynamics · 2015 · 19 citations
    10. Genome-wide association study in Japanese females identifies fifteen novel skin-related trait associations Scientific reports · 2018 · 58 citations
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