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    Did you mean Agouti Signaling Protein?
    Glossary Agouti Signaling Protein

    protein influencing hair color by inhibiting melanocortin 1 receptor

    Agouti Signaling Protein (ASIP) is a protein that plays a crucial role in determining hair color in mammals. It works by inhibiting the action of the melanocortin 1 receptor (MC1R), which leads to the production of yellow or red pigments (pheomelanin) instead of black or brown pigments (eumelanin). This protein is also involved in various biological processes, including energy metabolism and obesity.

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    Research 30 of 182

    1. Bone morphogenetic protein (BMP) signaling controls hair pigmentation by means of cross-talk with the melanocortin receptor-1 pathway Proceedings of the National Academy of Sciences · 2004 · 70 citations
    2. Comparative genome analyses reveal the unique genetic composition and selection signals underlying the phenotypic characteristics of three Chinese domestic goat breeds Genetics selection evolution · 2019 · 30 citations
    3. The Agouti Gene in Obesity: Central and Peripheral Mechanisms, and Therapeutic Implications 2001
    4. Down-regulation of Melanocortin Receptor Signaling Mediated by the Amino Terminus of Agouti Protein in XenopusMelanophores Journal of Biological Chemistry · 1999 · 43 citations
    5. Agouti and Agouti-related Protein: Analogies and Contrasts Journal of Biological Chemistry · 2000 · 135 citations
    6. An Intrinsic Oscillation of Gene Networks Inside Hair Follicle Stem Cells: An Additional Layer That Can Modulate Hair Stem Cell Activities Frontiers in Cell and Developmental Biology · 2020 · 23 citations
    7. The Role of gp91phox and the Effect of Tranexamic Acid Administration on Hair Color in Mice International Journal of Molecular Sciences · 2019 · 2 citations
    8. Resequencing Analyses Revealed Genetic Diversity and Selection Signatures during Rabbit Breeding and Improvement Genes · 2024
    9. Deciphering principles of morphogenesis from temporal and spatial patterns on the integument Developmental Dynamics · 2015 · 19 citations
    10. Genome-wide association study in Japanese females identifies fifteen novel skin-related trait associations Scientific reports · 2018 · 58 citations
    11. Expression and Distribution of the Guanine Nucleotide-binding Protein Subunit Alpha-s in Mice Skin Tissues and Its Association with White and Black Coat Colors Asian-Australasian journal of animal sciences · 2016 · 1 citations
    12. Expression and tissue distribution analysis of vimentin and transthyretin proteins associated with coat colors in sheep (Ovis aries) Animal Bioscience · 2023
    13. Greasy hair against obesity Signal transduction and targeted therapy · 2021
    14. β-catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair Developmental Cell · 2010 · 314 citations
    15. Hair Follicle Disruption Facilitates Pathogenesis to UVB-Induced Cutaneous Inflammation and Basal Cell Carcinoma Development in Ptch+/− Mice American Journal of Pathology · 2014 · 8 citations
    16. Genetic Ablation of the <i>CDP/Cux</i> Protein C Terminus Results in Hair Cycle Defects and Reduced Male Fertility Molecular and cellular biology · 2002 · 97 citations
    17. Regulation of stem cell function by protein ubiquitylation EMBO Reports · 2014 · 55 citations
    18. Dynamic regulation of retinoic acid-binding proteins in developing, adult and neoplastic skin reveals roles for β-catenin and Notch signalling Developmental biology · 2008 · 84 citations
    19. Mutations in Sterol O-Acyltransferase 1 (Soat1) Result in Hair Interior Defects in AKR/J Mice Journal of Investigative Dermatology · 2010 · 23 citations
    20. Sox2 in the dermal papilla regulates hair follicle pigmentation Cell reports · 2022 · 9 citations
    21. Hair Follicle Pigmentation 2005 · 450 citations
    22. Fibroblasts: Origins, definitions, and functions in health and disease Cell · 2021 · 488 citations
    23. Characterization of a new, inducible transgenic mouse model with GFP expression in melanocytes and their precursors Gene Expression Patterns · 2017 · 14 citations
    24. Identification of differentially expressed Gnαs and Gnα11 in sheep ( Ovis aries ) skins associated with white and black coat colors Acta histochemica · 2016 · 1 citations
    25. Fundamental hair follicle biology and fine fibre production in animals animal · 2010 · 170 citations
    26. Analyses of regenerative wave patterns in adult hair follicle populations reveal macro-environmental regulation of stem cell activity ˜The œInternational journal of developmental biology · 2009 · 64 citations
    27. Transcriptomic regulation of seasonal coat color change in hares Ecology and evolution · 2020 · 18 citations
    28. Skipping of Exons by Premature Termination of Transcription and Alternative Splicing within Intron-5 of the Sheep SCF Gene: A Novel Splice Variant PloS one · 2012 · 6 citations
    29. The Mechanisms of Fur Development and Color Formation in American Mink Revealed Using Comparative Transcriptomics Animals · 2022 · 1 citations
    30. Therapeutic strategy for hair regeneration: hair cycle activation, niche environment modulation, wound-induced follicle neogenesis, and stem cell engineering Expert Opinion on Biological Therapy · 2013 · 74 citations