This study found that circadian clock genes are involved in regulating the hair growth cycle, suggesting a connection between daily rhythms and the longer hair follicle cycling process.
2 citations
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December 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”
In this study, overexpression of miR-29 in mice led to aging-related phenotypes and early lethality, demonstrating its significant role in driving aging processes.
237 citations
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February 2016 in “Science Translational Medicine”
This study found that many effects previously thought to be caused by circadian rhythm disruption in Bmal1 knockout mice are actually due to BMAL1's properties unrelated to its clock function.
January 2021 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”
This study found that ageing in women leads to significant structural and biological changes in the scalp hair follicle environment, which may affect hair growth.
14 citations
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October 2021 in “Dermatology and Therapy”
This study found that photoexposure significantly increased the gene expression of altered elastin, MMP12, and LOX, as well as the protein expression of tropoelastin and fibrillin-1, in skin models.
Finasteride and oral minoxidil effectively maintain a youthful appearance and full head of hair, despite genetic predispositions to balding. The discussion also considers the impact of DHT blockers on masculinity and aging, with lifestyle choices like sunscreen use and a vegetarian diet mentioned.
Dutasteride is recommended for men on testosterone replacement therapy (TRT) with DHT-sensitive hair, as it does not interfere with TRT's anabolic effects and may improve libido and aging male symptoms. Users report varying experiences with libido when switching from finasteride to dutasteride, with some noticing improvements and others experiencing fluctuations.
A 25-year-old man is worried about his girlfriend noticing his balding and is frustrated by society's focus on looks. He uses minoxidil, finasteride, and dutasteride for hair loss and considers being honest with her.
A person improved hair loss from Norwood 3 to Norwood 2 using a topical formula with minoxidil, dutasteride, and tretinoin, plus oral minoxidil and red light therapy. There is skepticism about the treatment's effectiveness and concerns about misleading comparison photos.
Finasteride and dutasteride can improve skin texture and reduce acne by lowering DHT but do not reverse aging. They may enhance skin and hair health for some, but can also cause side effects like dry skin and sexual dysfunction.