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Glossary Adipocyte Precursor Cells

immature cells that can develop into fat-storing adipocytes

Adipocyte Precursor Cells, also known as preadipocytes, are immature cells that have the potential to develop into adipocytes, which are the cells responsible for storing fat in the body. These precursor cells play a crucial role in the formation and maintenance of adipose tissue, and their differentiation is influenced by various hormonal and environmental factors. Understanding these cells is important for research into obesity, metabolic disorders, and tissue regeneration.

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research Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling

499 citations , September 2011 in “Cell”

This study found that intradermal adipocyte lineage cells in mice are necessary and sufficient to activate follicular stem cells, highlighting their role in regulating skin stem cell activity.

research The Role of Adipocytes in Tissue Regeneration and Stem Cell Niches

42 citations , May 2016 in “Annual Review of Cell and Developmental Biology”

This review explores the novel roles of white adipose tissue in tissue homeostasis and regeneration, emphasizing its impact on epithelial, muscle, and immune tissues, and reports no new clinical results.

research PDGFA regulation of dermal adipocyte stem cells

3 citations , September 2017 in “Stem cell investigation”

This review discusses the various roles of skin-resident dermal white adipose tissue in hair growth inhibition, antibacterial responses, and wound healing, reporting no new empirical findings.

Knockout of mTOR/Akt Inhibitor REDD1 Results in Hair Cycle-Independent Dermal Adipose Expansion by Promoting Adipocyte Differentiation

research 976 Knockout of mTOR/Akt inhibitor REDD1 results in hair cycle-independent dermal adipose expansion by promoting adipocyte differentiation

April 2019 in “Journal of Investigative Dermatology”

This study found that mice lacking REDD1 experienced an expansion of dermal white adipose tissue through both hypertrophy and hyperplasia, suggesting a potential therapeutic target for skin adipogenesis regulation.

research Hair follicles’ transit-amplifying cells govern concurrent dermal adipocyte production through Sonic Hedgehog

75 citations , October 2016 in “Genes & Development”

This study found that Sonic Hedgehog secreted by hair follicle transit-amplifying cells is essential for dermal adipogenesis and hair follicle growth by acting on adipocyte precursors.

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community Increased adipose tissue (being overweight) in males may increase likelyhood of finasterde side effects

in Research/Science 29 upvotes 2 years ago

Being overweight may increase finasteride side effects due to higher aromatase activity converting testosterone to estradiol. Maintaining a healthy weight could reduce these side effects.

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