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research Calcineurin-Based Immunosuppression in Renal Transplantation: Focus on Efficacy, the Role of Steroids, and Cardiovascular Risk

August 2021

Tacrolimus causes fewer acute rejections than cyclosporin A in kidney transplants but doesn't necessarily improve kidney function after one year; cardiovascular risks and side effects vary between the two drugs.

research Face Transplantation for Granulomatosis With Polyangiitis (Wegener Granulomatosis)

14 citations, January 2019 in “Annals of plastic surgery”

Face transplant for a severe autoimmune disease patient was successful, improving appearance and function without disease relapse after three years.

research UVB-Induced Depletion of Donor-Derived Dendritic Cells Prevents Allograft Rejection of Immune-Privileged Hair Follicles in Humanized Mice

6 citations, November 2018 in “American journal of transplantation”

UV light helped human hair transplants survive in mice without broad immunosuppression.

research Transplantation Immunology: Solid Organ and Bone Marrow

139 citations, February 2010 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology”

Transplant success has improved with better immunosuppressive drugs and donor matching.

research CAQ Corner: Basic Concepts of Transplant Immunology

May 2022 in “Liver transplantation”

The document explains how the immune system reacts to organ transplants and the treatments used to prevent rejection.

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community Creatine's effect on Hair Loss and DHT

in Research/Science 102 upvotes 9 months ago

A 21-year-old male managed to control his hair loss using Nizoral, RU58841, and finasteride, but experienced increased scalp itchiness after starting creatine, which subsided upon stopping creatine. Users shared mixed experiences on whether creatine affects hair loss, with some reporting negative effects and others seeing no change or defending its benefits.

community 4-month Min - Diffuse thinking update

in Progress Pictures 618 upvotes 5 months ago

User shared a 4-month progress update on using minoxidil and 1.5 months on finasteride for hair loss. Reactions were mixed, with some expressing disbelief and others feeling inspired to start treatment.

community I’m just Going to let Nature take its Course

in Chat 213 upvotes 1 year ago

The post and conversation are about a 23-year-old deciding to stop using finasteride for hair loss due to potential erectile dysfunction risks, sparking a debate about the benefits and side effects of hair loss treatments.

community Everyone is ignoring that plasma finasteride levels are 100x lower with topical compared to oral.

in Research/Science 138 upvotes 5 months ago

Topical finasteride results in plasma levels 100 times lower than oral finasteride, potentially reducing systemic side effects. Users report similar efficacy with fewer side effects, suggesting a preference for topical application.

community Brutal ongoing Shed after 15 months on fin

in Treatment 7 upvotes 1 year ago

User is experiencing severe hair loss despite using finasteride for 15 months, losing 500 hairs a day and 50% density since June. Minoxidil with needling was ineffective, and RU58841 is too expensive and hard to obtain.

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