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Normal Fur Development and Sebum Production Depend on Fatty Acid 2-Hydroxylase Expression in Sebaceous Glands

research Normal Fur Development and Sebum Production Depends on Fatty Acid 2-Hydroxylase Expression in Sebaceous Glands

40 citations , June 2011 in “Journal of biological chemistry/The Journal of biological chemistry”

This study revealed that deficiency in the enzyme FA2H in mice affected sebaceous gland function, altered sebum composition, and caused cycling alopecia, highlighting FA2H's role in hair follicle homeostasis.

Annurca Apple Polyphenols Ignite Keratin Production in Hair Follicles by Inhibiting the Pentose Phosphate Pathway and Amino Acid Oxidation

research Annurca Apple Polyphenols Ignite Keratin Production in Hair Follicles by Inhibiting the Pentose Phosphate Pathway and Amino Acid Oxidation

18 citations , October 2018 in “Nutrients”

This study found that Annurca apple polyphenolic extracts reprogram hair follicle metabolism in mice, enhancing mitochondrial activity and keratin production while inhibiting some metabolic pathways.

Perturbations in Fatty Acid Metabolism and Collagen Production Infer Pathogenicity of a Novel MBTPS2 Variant in Osteogenesis Imperfecta

research Perturbations in fatty acid metabolism and collagen production infer pathogenicity of a novel MBTPS2 variant in Osteogenesis imperfecta

1 citations , May 2023 in “Frontiers in endocrinology”

The researchers reported that the novel MBTPS2 variant p.Glu172Asp found in a male proband is likely pathogenic, consistent with osteogenesis imperfecta symptoms and molecular signatures, including disrupted fatty acid metabolism and collagen production.

research Prediction and Demonstration of Retinoic Acid Receptor Agonist Ch55 as an Antifibrotic Agent in the Dermis

3 citations , February 2023 in “Journal of Investigative Dermatology”

Ch55 may help reduce skin scarring and fibrosis.

research Increased dipicolinic acid production with an enhanced spoVF operon in Bacillus subtilis and medium optimization

12 citations , November 2014 in “Bioscience, Biotechnology, and Biochemistry”

In this study, the researchers successfully increased dipicolinic acid production in Bacillus subtilis by genetically modifying the spoVF operon, achieving a significant productivity improvement in the culture medium.

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learn vitamin b2

How does Vitamin B5 (Pantothenic Acid) support hair strength and thickness? Vitamin B5 supports hair strength and thickness by aiding energy production in hair follicles.

learn Thymosin Beta 4

learn Tretinoin

the gold standard retinoid in dermatology that's also helpful for hair regrowth alongside Minoxidil

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Rosemary

herb and oil with stimulant, circulatory, anti-inflammatory and antioxidant properties

learn Overview

learn Azelaic Acid

Is azelaic acid a treatment on its own or does it need supplements? One small randomised trial (26 women) found 5% azelaic acid comparable to 2% minoxidil in female pattern hair loss, and the anti-DHT rationale otherwise rests on in-vitro work — community members generally describe azelaic acid as an add-on to minoxidil or finasteride rather than a standalone treatment.
azelaic acid: Does it work for all types of hair loss or just DHT? One small randomised trial (26 women) found 5% azelaic acid comparable to 2% minoxidil for female pattern hair loss, and the anti-DHT rationale rests on laboratory work; for alopecia areata, telogen effluvium and seborrhoeic dermatitis there is no trial evidence for azelaic acid at all.
What happens if I mix azelaic acid with minoxidil or regular hair loss shampoos? Mixing azelaic acid with minoxidil or hair loss shampoos is generally safe and may enhance effectiveness.
All 4 questions on Azelaic Acid →

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community RU58841 to stop excessive oil production?

in Research/Science 7 upvotes 2 years ago

The user discusses using Minoxidil for hair loss and is considering RU58841 to reduce excessive oil production. They seek advice on RU58841's effectiveness in blocking sebum production.

community Salicylic Acid shampoo while on minoxidil. Is it okay?

15 upvotes 5 years ago

Minoxidil users can safely use salicylic acid shampoo to manage scalp pimples and dandruff. Nizoral is also recommended for hair gain and treating scalp pimples.

community Source for topical valproic acid?

2 upvotes 8 months ago

The conversation is about finding a source for topical valproic acid for hair regrowth. The user mentions PP405 and the unavailability of products from certain suppliers.

community Why plain Azelaic acid is a safe and effective product for hairloss that makes Finasteride an obsolete treatment for male pattern baldness.

7 upvotes 12 years ago

The conversation discusses the effectiveness of Azelaic acid for hair loss, suggesting it may make Finasteride an outdated treatment for male pattern baldness. Specific treatments mentioned include Minoxidil, Finasteride, and RU58841.

community Theoretically won't this be better than finasteride? Azelaic acid + zinc

9 upvotes 3 years ago

The conversation discusses using zinc sulphate and azelaic acid to inhibit 5 alpha-reductase activity, which could potentially treat androgen-related skin conditions like hair loss. Combining these with vitamin B6 could enhance the effect, potentially offering an alternative to finasteride.

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