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research Acid phosphatase distribution in the wool follicle. III. Fate of organelles in keratinized cells

6 citations , June 1976 in “Journal of ultrastructure research”

This study identified the presence of recognizable organelles, such as lysosomes and mitochondria, in both the keratinized fiber and the hardened inner root sheath of the Romney wool follicle.

research Distribution of acid and alkaline phosphatases in canine skin.

3 citations , December 1975 in “PubMed”

This study found that acid and alkaline phosphatases serve different functions in Beagle dog skin, with ALP primarily involved in growth processes and ACP in phospholipid breakdown.

research Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells

85 citations , April 2012 in “PLOS ONE”

This study found that valproic acid promoted hair re-growth in C3H mice by activating the Wnt/β-catenin pathway, suggesting its potential as a treatment for alopecia.

Annurca Apple Polyphenols Ignite Keratin Production in Hair Follicles by Inhibiting the Pentose Phosphate Pathway and Amino Acid Oxidation

research Annurca Apple Polyphenols Ignite Keratin Production in Hair Follicles by Inhibiting the Pentose Phosphate Pathway and Amino Acid Oxidation

18 citations , October 2018 in “Nutrients”

This study found that Annurca apple polyphenolic extracts reprogram hair follicle metabolism in mice, enhancing mitochondrial activity and keratin production while inhibiting some metabolic pathways.

research Simultaneous Typing of Erythrocyte Acid Phosphatase, Adenylate Kinase and Adenosine Deaminase in Human Hair Root Sheaths

1 citations , September 1986 in “Journal of the Forensic Science Society”

This study found that hair root sheaths can be accurately typed for erythrocyte acid phosphatase, adenylate kinase, and adenosine deaminase, consistent with blood typing results from the same donors.

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learn Valproic acid

an anticonvulsant repurposed for hair loss via histone inhibition

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learn Azelaic Acid

acid used for antimicrobial, anti-inflammatory and anti-androgenic properties

Is azelaic acid a treatment on its own or does it need supplements? One small randomised trial (26 women) found 5% azelaic acid comparable to 2% minoxidil in female pattern hair loss, and the anti-DHT rationale otherwise rests on in-vitro work — community members generally describe azelaic acid as an add-on to minoxidil or finasteride rather than a standalone treatment.
azelaic acid: Does it work for all types of hair loss or just DHT? One small randomised trial (26 women) found 5% azelaic acid comparable to 2% minoxidil for female pattern hair loss, and the anti-DHT rationale rests on laboratory work; for alopecia areata, telogen effluvium and seborrhoeic dermatitis there is no trial evidence for azelaic acid at all.
What happens if I mix azelaic acid with minoxidil or regular hair loss shampoos? Mixing azelaic acid with minoxidil or hair loss shampoos is generally safe and may enhance effectiveness.
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community P-1075: a BETTER version of Minoxidil

11 months ago

P-1075 is a more potent hair growth agent than Minoxidil, but it poses significant heart risks, making it unsafe for use. Despite promising results in macaques, concerns about its cardiotoxicity in rats have halted its development.

community Peptides that Stop Hair Loss? | In-depth Literature Review Video

76 upvotes 2 years ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

community Novel Formulation To Put An End To Hair Loss Once And For All.

in Research/Science 118 upvotes 10 months ago

A pharmacy student proposed a hair loss treatment using minoxidil, finasteride, clascoterone, and tretinoin, aiming for high effectiveness with minimal side effects. Reactions were mixed, with some questioning its feasibility and others showing interest.

community Why can’t we just do another creatine study?

153 upvotes 1 year ago

Creatine may worsen hair loss in some, especially with androgenic alopecia, but evidence is mixed. Some users experience no hair loss when using creatine with minoxidil and finasteride, while others notice increased shedding.

community Results are in for my experiment with Creatine/Fin

129 upvotes 6 years ago

Creatine use with finasteride increased DHT levels, possibly affecting hair loss. The user plans to reduce creatine to stabilize DHT and hair shedding.

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