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Glossary Folic Acid

essential for DNA synthesis and cell division

Folic acid, also known as Vitamin B9 or folate, is a water-soluble vitamin essential for DNA synthesis, cell division, and proper brain function. It is particularly important during periods of rapid growth, such as pregnancy and infancy, and is commonly found in leafy green vegetables, legumes, and fortified foods. Deficiency in folic acid can lead to anemia and, in pregnant women, an increased risk of neural tube defects in the developing fetus.

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Can folic acid help reduce hair loss in men and women, and how should it be taken? Correcting a confirmed folate deficiency is reasonable, but no published trial shows folic acid supplementation reduces hair loss on its own; the evidence is a few small observational studies and reviews that call for proper trials.
Is there a difference between taking folic acid supplements and using folic acid in topical hair products? Oral folic acid uses the body's normal absorption route and can correct a measured deficiency, but no published trial shows it treats hair loss; topical folic acid has no human evidence for hair growth and struggles to cross the skin barrier at all.
How does folic acid support hair follicle health and growth at a cellular level? Folate is required for the DNA synthesis that fast-dividing hair matrix cells depend on, and severe deficiency causes anemia—but no published trial has given folic acid to people with hair loss and measured the result, so a growth effect is a mechanism, not a finding.
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research Serum holotranscobalamine, vitamin B12, folic acid and homocysteine levels in alopecia areata patients

13 citations , May 2012 in “Cutaneous and ocular toxicology”

In this study, researchers found no significant differences in vitamin B12, folate, and homocysteine metabolism between patients with alopecia areata and controls, suggesting no association with vitamin B12 deficiency.

research Evaluation of Zinc, Vitamin B12, Folic Acid and Iron Levels and Thyroid Functions in Patients with Chronic Telogen Effluvium

2 citations , December 2015 in “Journal of dermatology research and therapy”

This study compared serum zinc, vitamin B12, folic acid levels, iron metabolism, and thyroid function between chronic telogen effluvium patients and healthy controls, but it reports no specific clinical results.

research G.P.2.16 Valproate, acetylcarnitine, folic acid and vitamin B12 in spinal muscular atrophy: Preliminary data of an open-label study in children

1 citations , September 2007 in “Neuromuscular disorders”

This study suggests that long-term treatment with valproate, acetylcarnitine, folic acid, and vitamin B12 may benefit children with SMA types II and III by improving muscle strength and function without significant adverse effects.

research Folic acid therapy for alopecia in a Charolais calf

1 citations , November 1988 in “Veterinary Record”

In this case study, oral folic acid therapy resulted in noticeable improvement and eventual recovery from hair loss and skin issues in a three-week-old Charolais calf.

research Evaluation of serum substance P,folic acid and ferritin in female patients with hair fall and trichodynia

July 2025 in “ALEXMED ePosters”

In this study, the researchers aimed to evaluate the levels of substance P, folic acid, and ferritin in the serum of female patients experiencing hair fall and trichodynia.

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Hair Loss Treatments
Folica Hair CareVijayawada, Andhra Pradesh · IN

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