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research Androgenic Alopecia: Pathogenetic Mechanisms and Therapeutic Approaches

June 2013

The document concludes that current treatments for androgenic alopecia are not fully effective, but new therapies like botulinum toxin and PRP show promise, and future gene therapy could be beneficial.

Treatment of Male Rats with Finasteride, an Inhibitor of 5alpha-Reductase Enzyme, Induces Long-Lasting Effects on Depressive-Like Behavior, Hippocampal Neurogenesis, Neuroinflammation, and Gut Microbiota Composition

research Treatment of Male Rats with Finasteride, an Inhibitor of 5alpha-Reductase Enzyme, Induces Long-Lasting Effects on Depressive-Like Behavior, Hippocampal Neurogenesis, Neuroinflammation, and Gut Microbiota Composition

37 citations, September 2018 in “Psychoneuroendocrinology”

Finasteride treatment in male rats causes long-lasting effects on depression-like behavior, brain cell growth, inflammation, and gut bacteria composition.

research Two Cases of Paradoxical Nonscarring Alopecia After Mesotherapy with Dutasteride

August 2021 in “Skin appendage disorders”

Two people lost hair unexpectedly after getting a common hair loss treatment with a drug called Dutasteride.

Physiopathological Role of the Enzymatic Complex 5α-Reductase and 3α/β-Hydroxysteroid Oxidoreductase in the Generation of Progesterone and Testosterone Neuroactive Metabolites

research Physiopathological Role of the Enzymatic Complex 5α-Reductase and 3α/β-Hydroxysteroid Oxidoreductase in the Generation of Progesterone and Testosterone Neuroactive Metabolites

18 citations, March 2020 in “Frontiers in Neuroendocrinology”

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

research The Potential of Androgenic Alopecia Management from Plant Derivatives

1 citations, August 2020 in “Food Research”

Plant extracts like Avicennia marina, Boehmeria nipononivea, and Camellia sinensis could potentially treat hair loss with fewer side effects than synthetic drugs.

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community Finasteride affects both 5a reductase and 5b reductase

6 upvotes 5 years ago

Finasteride not only inactivates the 5a reductase enzyme but also affects the 5b reductase enzyme in a dose-dependent manner, which can impact sexual behavior and brain activity. The user experienced significant hair regrowth and side effects on 1mg of finasteride, which diminished after reducing the dose to 0.5mg, leading to no side effects and further hair improvement.

community Increased adipose tissue (being overweight) in males may increase likelyhood of finasterde side effects

in Research/Science 30 upvotes 5 months ago

Being overweight may increase finasteride side effects due to higher aromatase activity converting testosterone to estradiol. Maintaining a healthy weight could reduce these side effects.

community Fin/Dut and Metabolism Speeds…

in Finasteride/Dutasteride 8 upvotes 6 months ago

A user speculates that a fast metabolism might affect the effectiveness of dutasteride for hair loss. Another user argues that drug response is unrelated to metabolism speed.

community 5 Months Finasteride + Minoxidil

in Progress Pictures 676 upvotes 2 years ago

This user has achieved impressive results after 5 months of using Finasteride and Minoxidil, which appear to have stopped hair loss and stimulated new growth. They have also incorporated derma pen treatments and supplements such as Zinc picolinate and DMAE into their regimen.

community Why I deleted my YouTube channel Part I

in Update 118 upvotes 3 years ago

A YouTuber named Kevin, also known as Rider_Of_Roach, who deleted his YouTube channel due to personal attacks and controversy surrounding his views on hair loss treatments. He advocated for FDA-approved treatments like finasteride and minoxidil but faced backlash from those who disagreed with him. The conversation also discusses his past trolling behavior and a lawsuit he filed against a website that published false information about him. Despite some disagreements, many viewers appreciated his research-based content and hope to see him return in the future.

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