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    Research 10 of 1000+

    1. Steroid 5α-reductase 2 deficiency leads to reduced dominance-related and impulse-control behaviors Psychoneuroendocrinology · 2018 · 14 citations
    2. Inhibition of steroid 5 alpha-reductase with finasteride: sleep-related erections, potency, and libido in healthy men. The Journal of Clinical Endocrinology and Metabolism · 1995 · 15 citations
    3. 5α-Reduced glucocorticoids: a story of natural selection Journal of Endocrinology · 2011 · 46 citations
    4. Identification of Anabolic Selective Androgen Receptor Modulators with Reduced Activities in Reproductive Tissues and Sebaceous Glands 2009 · 36 citations
    5. Natural Product-Inspired Bis(trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, <i>In Vitro</i>, and <i>In Silico</i> Studies ACS Omega · 2025
    6. Sexual dimorphism of growth plate prehypertrophic and hypertrophic chondrocytes in response to testosterone requires metabolism to dihydrotestosterone (DHT) by steroid 5‐alpha reductase type 1 Journal of Cellular Biochemistry · 2005 · 27 citations
    7. Finasteride-induced depression: new insights into possible pathomechanisms Journal of Cosmetic Dermatology · 2010 · 22 citations
    8. Synthesis and biological evaluation of novel unsaturated carboxysteroids as human 5α-reductase inhibitors: A legitimate approach European journal of medicinal chemistry · 2012 · 17 citations
    9. Activity of steroid 4 and derivatives 4a–4f as inhibitors of the enzyme 5α-reductase 1 Bioorganic & medicinal chemistry · 2018 · 3 citations
    10. Comprehensive Evaluation of <i>Tectona grandis</i> L.f.: Integrated <i>In Vitro</i> and <i>In Silico</i> Analysis of Steroid 5α-Reductase Inhibition and Anti-Inflammatory Properties ACS Omega · 2025
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    Community 10 of 1000+

    1. How finasteride lowers brain's happiness steroid allopregnanolone and causes depression: systemic dihydroprogesterone crosses blood brain barrier, you don't even need finasteride and brain 5ar for that Reddit · 31 May 2025
    2. Does everything that reduces DHT block 5ar? Reddit · 2 May 2024
    3. Topical Finasteride Doesn't Directly Reduce 5ar Enzyme on Scalp Reddit · 19 May 2023
    4. If we lose hair because of our sensitivity to DHT, then why are we trying to reduce DHT when our sensitive androgen receptors are the culprit? Reddit · 6 Apr 2022
    5. 4 months on oral dutasteride + one month and 3 weeks on topical minoxidil 5% Reddit · 23 May 2026
    6. Dutasteride Literally Saves Your Hair Reddit · 16 Jun 2024
    7. Does Topical Finasteride Directly Reducing Scalp DHT? Reddit · 17 May 2023
    8. How significant is the difference between 0.5mg Dut and 1mg Fin? Reddit · 7 Jun 2024
    9. Explanation for "dutasteride destroyed my hair" Reddit · 29 May 2024
    10. Anecdotal, but: Adding RU58841 has stopped my Dutasteride shed Reddit · 26 Nov 2023
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    Learn 4 of 24

    1. Neem Oil Oil from the neem tree, used in traditional remedies
    2. Finasteride Popular 5-alpha reductase inhibitor that lowers DHT, taken as a pill or used topically
    3. Dutasteride 5-alpha reductase inhibitor that blocks both enzyme types, a stronger DHT blocker than finasteride
    4. Saw Palmetto Palm-berry extract taken as a supplement
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