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Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Finasteride may increase depression by reducing brain cell growth.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

The enzyme 5α-reductase type 1 is important for blood vessel development and fertility in the uterus.

The enzyme 5α-reductase is important for proper blood vessel development during the fertility-related transformation of the uterus lining.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.

Finasteride can cause sexual problems and depression in young men.

Finasteride might affect memory by impacting cholinergic system.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

5α-reductase inhibitors can cause serious and possibly lasting sexual and psychological side effects.

Early changes in brain chemicals affect how a drug reduces alcohol intake in rats.

Men with liver cancer have higher levels of a specific testosterone byproduct in their liver and blood, despite overall lower male hormone levels.

Finasteride treatment can decrease certain steroids and increase others, possibly leading to depression symptoms in some cases.

Medications for enlarged prostate can cause sexual side effects like reduced libido, erectile dysfunction, and ejaculatory problems.

Low dose finasteride decreases certain steroids, possibly increasing depression risk.

We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.

Early NAS level changes affect alcohol consumption vulnerability.

Allopregnanolone is needed for certain brain processing issues caused by D1 dopamine receptor activation.

Enzymes called 5α-reductases have many body functions and need more research to safely use inhibitors.

5-alpha reductase inhibitors slightly increase the risk of sexual and mood side effects, and breast growth in men.

Finasteride almost fully depletes allopregnanolone in rat brains and enhances 20α-DHP, but doesn't change 3α-DHP levels.

Finasteride treats enlarged prostate and hair loss, but may cause side effects in some patients.

Certain steroids in the brain affect mood and symptoms of depression, and treatments targeting these steroids show promise for improving these symptoms.

Inhibiting 5α-reductase increases progesterone levels in late pregnant mares.

Certain 4-azasteroids are effective at blocking the enzyme that processes testosterone in human skin and could help treat acne, excessive hair growth, and male pattern baldness.

Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

Finasteride reduces new brain cells in male mice, possibly causing depression.

Dihydrotestosterone and 5α-Reductase play a role in hair loss and prostate health, and finasteride can increase hair growth in men without affecting sperm production, but it doesn't work for postmenopausal women with hair loss.

Prostate cancer prevention includes diet changes, supplements, and medications, with more answers expected soon.