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    Glossary 5α-reductase inhibitors

    block enzyme converting testosterone to hair-loss-causing DHT

    5α-reductase inhibitors, also known as 5-ARIs, are medications that block the enzyme 5α-reductase. This enzyme converts testosterone into dihydrotestosterone (DHT), a hormone that can contribute to conditions like male pattern baldness and benign prostatic hyperplasia (BPH). By inhibiting this enzyme, 5-ARIs can help reduce hair loss and shrink an enlarged prostate.

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    Research 10 of 1000+

    1. Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor 2004 · 408 citations
    2. DIHYDROTESTOSTERONE AND THE PROSTATE: THE SCIENTIFIC RATIONALE FOR 5α-REDUCTASE INHIBITORS IN THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIA 2004 · 235 citations
    3. Adverse Side Effects of 5α‐Reductase Inhibitors Therapy: Persistent Diminished Libido and Erectile Dysfunction and Depression in a Subset of Patients The Journal of Sexual Medicine · 2010 · 223 citations
    4. An overview on 5α-reductase inhibitors Steroids · 2009 · 219 citations
    5. The Risks and Benefits of 5α-Reductase Inhibitors for Prostate-Cancer Prevention 2011 · 147 citations
    6. Adverse effects of 5α-reductase inhibitors: What do we know, don’t know, and need to know? Reviews in Endocrine and Metabolic Disorders · 2015 · 111 citations
    7. Association of Suicidality and Depression With 5α-Reductase Inhibitors JAMA Internal Medicine · 2017 · 90 citations
    8. The Dark Side of 5α-Reductase Inhibitors' Therapy: Sexual Dysfunction, High Gleason Grade Prostate Cancer and Depression Korean Journal of Urology · 2014 · 75 citations
    9. Sexual dysfunction in subjects treated with inhibitors of 5α-reductase for benign prostatic hyperplasia: a comprehensive review and meta-analysis International Journal of Andrology · 2017 · 66 citations
    10. The efficacy and safety of 5α-reductase inhibitors in androgenetic alopecia: a network meta-analysis and benefit–risk assessment of finasteride and dutasteride Journal of Dermatological Treatment · 2013 · 66 citations
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    Community 10 of 20

    1. Androsterone as a Neurosteroid Replacement Strategy for 5α-Reductase Inhibitor–Associated Sexual and Affective Dysfunction Reddit · 15 Jul 2026
    2. FCE 28260: A Forgotten 5α-Reductase Inhibitor Community · 22 Aug 2024
    3. 1 month of using fin, so happy Reddit · 14 Aug 2024
    4. We are manipulating our hormones, surely it's prudent to track bloodwork ? Reddit · 19 Apr 2024
    5. Re:you (NOVOGRO) New Hair Loss Treatment Coming in August Reddit · 24 Jun 2026
    6. He is claiming, he can treat alopecia Reddit · 5 Jan 2026
    7. The truth about Dutasteride (w/ sources) Reddit · 24 Jan 2023
    8. pumpkin seed oil? Reddit · 22 Sept 2016
    9. Does caffeine inhibit 5-α-reductase? Reddit · 27 Dec 2019
    10. When you think about it blocking dht is not that big of a deal as it’s made out to be Reddit · 23 Feb 2026
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    Learn 1

    1. Dutasteride 5-alpha reductase inhibitor that blocks both enzyme types, a stronger DHT blocker than finasteride