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Glossary11β-Hydroxysteroid Dehydrogenase Type 1

enzyme converting inactive cortisone to active cortisol

11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) is an enzyme that converts inactive cortisone into active cortisol, a hormone involved in stress response, metabolism, and immune function. This enzyme is found in various tissues, including the liver and adipose tissue, and plays a role in conditions like obesity, diabetes, and potentially hair loss due to its influence on local cortisol levels.

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research 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors for the Treatment of Type 2 Diabetes

43 citations , August 2010 in “Expert Opinion on Investigational Drugs”

Inhibitors of 11β-HSD1 show potential for treating type 2 diabetes but require more testing for safety and effectiveness.

research 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition Attenuates the Adverse Effects of Glucocorticoids on Dermal Papilla Cells

3 citations , January 2017 in “Yonsei Medical Journal”

Blocking 11β-HSD1 can lessen the harmful effects of glucocorticoids on hair growth cells.

research 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition Attenuates the Adverse Effects of Glucocorticoids on Dermal Papilla Cells

1 citations , September 2017 in “Journal of Investigative Dermatology”

Blocking a specific enzyme can reduce the negative impact of stress hormones on hair growth cells.

research 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition Attenuates the Adverse Effects of Glucocorticoids on Dermal Papilla Cells

September 2017

Blocking 11β-HSD1 reduces stress hormone damage in hair growth cells.

research Localization, Age- and Site-Dependent Expression, and Regulation of 11β-Hydroxysteroid Dehydrogenase Type 1 in Skin

119 citations , August 2010 in “Journal of Investigative Dermatology”

Increased 11β-HSD1 activity in skin may contribute to aging and could be targeted to reduce aging effects.

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community You will lose hair if your prostaglandins aren't in balance

in Research/Science 54 upvotes 10 months ago

Prostaglandin balance affects hair loss, particularly in conditions like Lichen Planopilaris, where an imbalance can lead to hair follicle damage. Treatments mentioned include prostaglandin analogs and Pioglitazone HCL, with a focus on maintaining prostaglandin equilibrium for potential hair regrowth.