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    Glossary 11β-Hydroxysteroid Dehydrogenase Type 1

    enzyme converting inactive cortisone to active cortisol

    11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) is an enzyme that converts inactive cortisone into active cortisol, a hormone involved in stress response, metabolism, and immune function. This enzyme is found in various tissues, including the liver and adipose tissue, and plays a role in conditions like obesity, diabetes, and potentially hair loss due to its influence on local cortisol levels.

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    Research 30 of 158

    1. Localization, Age- and Site-Dependent Expression, and Regulation of 11β-Hydroxysteroid Dehydrogenase Type 1 in Skin Journal of Investigative Dermatology · 2010 · 119 citations
    2. Mechanisms of Disease: selective inhibition of 11β-hydroxysteroid dehydrogenase type 1 as a novel treatment for the metabolic syndrome Nature Clinical Practice Endocrinology & Metabolism · 2005 · 69 citations
    3. 11β-Hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of type 2 diabetes Expert Opinion on Investigational Drugs · 2010 · 43 citations
    4. Expression of 11β-hydroxysteroid dehydrogenase type 1 in visceral and subcutaneous adipose tissues of patients with polycystic ovary syndrome is associated with adiposity The Journal of Steroid Biochemistry and Molecular Biology · 2010 · 18 citations
    5. 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition Attenuates the Adverse Effects of Glucocorticoids on Dermal Papilla Cells Yonsei Medical Journal · 2017 · 3 citations
    6. 258 11β-hydroxysteroid dehydrogenase type 1 inhibition attenuates the adverse effects of glucocorticoids on dermal papilla cells Journal of Investigative Dermatology · 2017 · 1 citations
    7. 11β-hydroxysteroid dehydrogenase type 1 inhibition attenuates the adverse effects of glucocorticoids on dermal papilla cells 2017
    8. 11α-Hydroxyprogesterone, a potent 11β-hydroxysteroid dehydrogenase inhibitor, is metabolised by steroid-5α-reductase and cytochrome P450 17α-hydroxylase/17,20-lyase to produce C11α-derivatives of 21-deoxycortisol and 11-hydroxyandrostenedione in vitro The Journal of Steroid Biochemistry and Molecular Biology · 2019 · 7 citations
    9. Modulation of glucocorticoid action and the treatment of type-2 diabetes Best Practice & Research Clinical Endocrinology & Metabolism · 2007 · 54 citations
    10. Targeting the pre-receptor metabolism of cortisol as a novel therapy in obesity and diabetes The Journal of Steroid Biochemistry and Molecular Biology · 2010 · 70 citations
    11. Delayed Diagnosis of Congenital Adrenal Hyperplasia Due to 3β-Hydroxysteroid Dehydrogenase Type 2 Deficiency JCEM Case Reports · 2025
    12. Evidence for Increased 5α-Reductase Activity During Early Childhood in Daughters of Women With Polycystic Ovary Syndrome The Journal of Clinical Endocrinology & Metabolism · 2016 · 40 citations
    13. Pre-receptor regulation of the androgen receptor Molecular and cellular endocrinology · 2007 · 56 citations
    14. Current evidence for the involvement of sex steroid receptors and sex hormones in benign prostatic hyperplasia Research and Reports in Urology · 2019 · 26 citations
    15. Ectoin attenuates cortisone‐induced skin issues by suppression GR signaling and the UVB‐induced overexpression of 11β‐HSD1 Journal of Cosmetic Dermatology · 2024
    16. Hirsutism-A Comprehensive Update of Embryology, Aetiopathogenesis and Therapeutic Approach Journal of gynecology and womens health · 2017 · 1 citations
    17. 5α-Reductase underscores the development of pectoral fin breeding tubercles in zebrafish Communications Biology · 2026
    18. Camellia nitidissima Flower Extract Alleviates Dermal Papilla Cell Dysfunction by Regulating 11β-HSD1 and the TGF-β2/Smad and Wnt/β-Catenin Pathways Current Issues in Molecular Biology · 2026
    19. The Role of 11-Oxygenated Androgens and Endocrine Disruptors in Androgen Excess Disorders in Women International Journal of Molecular Sciences · 2024 · 7 citations
    20. 11-Oxyandrogens in Adolescents With Polycystic Ovary Syndrome Journal of the Endocrine Society · 2022 · 9 citations
    21. The Search for the Causes of Common Hyperandrogenism, 1965 to Circa 2015 Endocrine Reviews · 2024 · 10 citations
    22. Wound Healing Impairment in Type 2 Diabetes Model of Leptin-Deficient Mice—A Mechanistic Systematic Review International Journal of Molecular Sciences · 2022 · 10 citations
    23. Intracrine androgen biosynthesis, metabolism and action revisited Molecular and Cellular Endocrinology · 2017 · 131 citations
    24. Alternative androgen pathways WikiJournal of Medicine · 2023
    25. 5α-Reductase Type 2 Regulates Glucocorticoid Action and Metabolic Phenotype in Human Hepatocytes Endocrinology · 2015 · 54 citations
    26. Challenges in treatment of patients with non-classic congenital adrenal hyperplasia Frontiers in Endocrinology · 2022 · 4 citations
    27. The anti-inflammatory and analgesic activities of 2Br-Crebanine and Stephanine from Stephania yunnanenses H. S.Lo Frontiers in Pharmacology · 2023 · 17 citations
    28. Congenital Adrenal Hyperplasia IntechOpen eBooks · 2022
    29. Cross‐sectional relation of long‐term glucocorticoids in hair with anthropometric measurements and their possible determinants: A systematic review and meta‐analysis Obesity Reviews · 2021 · 30 citations
    30. Effects of mitotane treatment on human steroid metabolism: implications for patient management Endocrine Connections · 2012 · 26 citations