Increased Expression of Zyxin and Its Potential Function in Androgenetic Alopecia

The study investigated the role of Zyxin (ZYX) in androgenetic alopecia (AGA), a common form of hair loss. Researchers found that ZYX expression was elevated in the affected frontal hair follicles of AGA patients compared to unaffected areas. In vivo experiments with ZYX knockout mice showed enhanced hair growth, while ex vivo and in vitro studies demonstrated that reducing ZYX expression increased hair shaft production and dermal papilla cell proliferation. RNA-seq analysis identified pathways involved in ZYX's role in AGA. The findings suggested that ZYX might contribute to AGA pathogenesis and could be a potential therapeutic target.