Botulinum Toxin A as an Alternative Treatment for Folliculitis Decalvans

March 2023 in “ JAAD case reports ”

Simone R.N.G. Neri, Márcia Regina Franzolin, Célia Luíza Petersen Vitello Kalil, N. S. Michalany, Alexandre Michalany, Marta O. Domingos

botulinum toxin A folliculitis decalvans scarring alopecia hair loss antibiotics corticosteroids intradermal sessions immune response Botox

Studysummary In this study, researchers reported that conventional treatments for folliculitis decalvans, which include steroids and antibiotics, are often ineffective, with many patients experiencing frequent recurrences of this scarring scalp disorder.

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Research cited in this study

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research Effectiveness and Safety of Botulinum Toxin Type A in the Treatment of Androgenetic Alopecia

15 citations , January 2020 in “BioMed Research International”

In this study of patients with androgenetic alopecia, botulinum toxin type A was found to significantly increase hair counts and improve hair density and coverage, with enhanced results observed when combined with oral finasteride, revealing a safe and effective treatment approach without adverse effects.

Folliculitis Decalvans: Effectiveness of Therapies and Prognostic Factors in a Multicenter Series of 60 Patients with Long-Term Follow-Up

research Folliculitis Decalvans: Effectiveness of Therapies and Prognostic Factors in a Multicenter Series of 60 Patients with Long-Term Follow-Up

41 citations , June 2018 in “Journal of The American Academy of Dermatology”

This study examined the therapeutic response to folliculitis decalvans treatments among 60 patients and found that earlier disease onset was linked to more severe cases, while a combination of rifampicin, clindamycin, tetracyclines, and intralesional steroids was most effective in controlling symptoms.

research Folliculitis Decalvans: A Multicenter Review of 82 Patients

68 citations , February 2015 in “Journal of the European Academy of Dermatology and Venereology”

This study found that severe folliculitis decalvans was associated with its onset before age 25 and the presence of pustules, while tetracyclines and clindamycin plus rifampicin were effective treatments.

research Retrospective Review of Folliculitis Decalvans in 23 Patients with Course and Treatment Analysis of Long-Standing Cases

43 citations , January 2015 in “Journal of Cutaneous Medicine and Surgery”

This study found that most patients with folliculitis decalvans showed improvement and remission with oral antibiotics, although some experienced relapses and required prolonged treatment.

research Folliculitis Decalvans: A Rare Inflammatory Scalp Disorder

112 citations , July 2008 in “Dermatologic Therapy”

This review outlines the diagnosis and management of folliculitis decalvans, an inflammatory scalp disorder, and highlights Staphylococcus aureus and immune response deficiencies as key factors in its development.

research A Hot New Twist to Hair Biology: The Role of TRPV1 in Human Hair Growth Control

174 citations , April 2005 in “The American journal of pathology (Print)”

This study found that TRPV1 activation in human scalp hair follicles inhibited hair shaft elongation, suppressed proliferation, and induced apoptosis, suggesting TRPV1 as a potential target for managing hair growth and epithelial disorders.