Matters of the HAART: Ritonavir Induced CYP3A4 Inhibition of Intranasal Fluticasone Leading to Cushing's Syndrome

October 2023 in “ Journal of the Endocrine Society ”

Anand Ramachandran, Sarah Ghaith, Akshaya Ramachandran

ritonavir CYP3A4 inhibition fluticasone propionate Cushing’s syndrome exogenous steroid HAART HIV FP steroids

Studysummary In this case report, researchers highlight a 57-year-old HIV patient on ritonavir who developed Cushing’s syndrome from over-the-counter intranasal fluticasone, underscoring the risks of drug interactions and the importance of counseling patients about potential steroid ingredients in OTC products.

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