The Effect of Human Hair Keratin Hydrogel on Early Cellular Response to Sciatic Nerve Injury in a Rat Model

May 2013 in “ Biomaterials ”

Lauren A. Pace, Johannes F. Plate, Thomas L. Smith, Mark Van Dyke

keratin hydrogel human hair keratin Schwann cells myelin debris macrophage infiltration Wallerian degeneration nerve regeneration peripheral nerve repair

Studysummary In this study, the researchers found that a keratin hydrogel filler in nerve conduits led to earlier Schwann cell migration and improved cellular behaviors compared to other fillers in a rat sciatic nerve model.

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research Mechanical and Biological Properties of Keratose Biomaterials

140 citations , August 2011 in “Biomaterials”

This study observed that keratose, derived from human hair, integrated well in mouse tissue and remodeled with collagen, suggesting potential as a non-toxic biomaterial for regenerative applications.

research The Use of Keratin Biomaterials Derived from Human Hair for the Promotion of Rapid Regeneration of Peripheral Nerves

309 citations , October 2007 in “Biomaterials”

This study found that a biomaterial gel made from human hair keratins facilitated nerve regeneration in an animal model, potentially matching the effectiveness of traditional autografts.