Wound Healing And Hair
April 2003
in “
Journal of Cutaneous Medicine and Surgery
”
alopecia areata diphenylcyclopropenone DPC matrix metalloproteinase 9 MMP-9 Langerhans cells dermis alopecia totalis topical minoxidil minoxidil 2% cyproterone acetate female androgenetic alopecia hyperandrogenism body mass index BMI iron L-lysine nutritional supplements heat shock proteins telogen effluvium AA DPC MMP-9 minoxidil Rogaine BMI iron L-lysine HSPs
TLDR Some treatments work better for different types of hair loss, and nutrients like iron and L-lysine are important for preventing hair loss.
The document presents several studies related to hair loss and treatments. One study investigated the early events during sensitization in patients with alopecia areata (AA) using diphenylcyclopropenone (DPC) and found an increase in matrix metalloproteinase 9 (MMP-9) expressing Langerhans cells in the dermis. This study involved 7 patients with severe AA and one with alopecia totalis. Another study compared the effects of topical minoxidil 2% and cyproterone acetate on female androgenetic alopecia over 12 months, involving 66 women. The study found that minoxidil was more effective in patients with isolated alopecia, while cyproterone acetate was more effective in patients with other signs of hyperandrogenism and a higher body mass index (BMI). Additionally, a review on nutritional factors and hair loss highlighted the importance of iron and L-lysine in preventing hair loss, cautioning against excessive intake of nutritional supplements. Other articles discussed the role of heat shock proteins in skin protection and repair, the epidemiology and genetics of AA, telogen effluvium, and methods for assessing hair loss. The document also touched on historical perceptions of alopecia areata.
