The Wound Healing Effect of Callicarpa Nudiflora in Scalded Rats

May 2019 in “ Evidence-based Complementary and Alternative Medicine ”

Xuguang Zhang, Xiu-min Li, Xinxin Zhou, Yong Wang, Weiyong Lai, Ying Liu, Yu-chao Luo, Junqing Zhang

Callicarpa nudiflora CNE Silver sulfadiazine epidermis dermis TNF-α IL-10 TGF-β1 VEGF Samd3 Callicarpa nudiflora extract Silvadene skin wound healing

Studysummary This study found that Callicarpa nudiflora water extract significantly accelerated wound healing and improved skin repair in deep second-degree scalds in rats, supporting its traditional medicinal use. Our plain-language summary of this paper — not a Tressless recommendation.

The study investigated the wound healing effects of Callicarpa nudiflora extract (CNE) on scalded rats, involving 40 rats divided into five groups. The 20% CNE-treated group showed significant improvements in wound closure and healing, with almost complete healing by day 21, compared to the control group. Histopathological examination revealed a mildly hypertrophic epidermis and intact dermis in the CNE-treated group. The study suggested that CNE could be a promising alternative for wound treatment, with fewer side effects than traditional treatments like silver sulfadiazine, due to its ability to upregulate VEGF and downregulate TGF-β1 and Smad3, contributing to scar reduction.

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This study reported that a novel liposomal formulation, SP-bFGF-SF-LIP, enhanced bFGF stability and skin permeability, significantly improving hair follicle recovery and wound healing in a mouse model.