Persistent Hyperandrogenic Symptoms in Midlife Women With PCOS: A Prospective Cohort Study in Sweden

    December 2022 in “ Biomedicines ”
    Sofia Persson, Kumari Ubhayasekera, Jonas Bergquist, Şahruh Türkmen, Inger Sundström‐Poromaa, Evangelia Elenis
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    Studysummary This study found that women diagnosed with PCOS who had hyperandrogenic symptoms at diagnosis were more likely to experience persistent androgenic symptoms and impaired quality of life in midlife.
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    The study involved 124 women diagnosed with Polycystic Ovary Syndrome (PCOS) and 74 age-matched controls, focusing on the persistence of hyperandrogenism, a common symptom of PCOS, into midlife. Results indicated that over 40% of the women with PCOS, and 82% of those who initially presented with hyperandrogenic symptoms, continued to suffer from hirsutism, a condition of unwanted, male-pattern hair growth. The free androgen index was higher in women with PCOS, regardless of weight. The study concluded that women with PCOS who initially present with hyperandrogenic symptoms have a higher risk of persistent androgenic symptoms and impaired quality of life in midlife.
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