Role of Vitamin D Supplementation Therapy on Ovulation and Insulin Resistance in Women with PCOS: A Randomized Controlled Trial

    March 2019 in “ Evidence Based Women Health Journal (Online) ”
    Sherif Akl, Sherif F El-Mekkawi, A M Elkotb, Afaf A. Mostafa
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    TLDR Vitamin D supplements increased ovulation rates in women with PCOS who were vitamin D deficient.
    In a study conducted from May 2015 to May 2017, 300 women diagnosed with polycystic ovary syndrome (PCOS) were examined to assess the safety and efficacy of vitamin D supplementation therapy on ovulation and metabolic changes. The results showed that the cumulative ovulation rate was significantly higher in the vitamin D deficient subgroup following vitamin D supplementation compared to the normal vitamin D subgroup and the control group, with a rate ratio of 1.27 and 1.22, respectively. The number needed to treat was calculated to be 5.34 and 6.38 compared to the normal vitamin D subgroup and control group respectively, meaning 6.38 women needed to be supplemented with vitamin D for one of them to benefit compared to control women. No significant differences were found in the median ovulating dose of clomiphene citrate or the cumulative clinical pregnancy rate between the ovulatory women of the three subgroups.
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