Nature-Derived Lignan Compound VB-1 Promotes Hair Growth by Augmenting Wnt/β-Catenin Signaling in Human Dermal Papilla Cells
May 2018
TLDR VB-1, a natural compound, may promote hair growth by enhancing important cell signaling and increasing key gene expression.
The study, conducted 5 years ago, investigated the effects of a nature-derived lignan compound, VB-1, on hair growth. The researchers found that VB-1 significantly promoted the proliferation of human dermal papilla cells (hDPCs) in a concentration-dependent manner. They discovered that VB-1 down-regulated DKK1, a protein involved in hair loss, and facilitated Wnt/β-catenin signaling, a pathway crucial for hair growth, in hDPCs. Additionally, the expression of dermal papilla signature genes was upregulated after VB-1 treatment. The researchers also found that VB-1 significantly promoted human hair follicle growth in an in vitro organ culture system. The study concluded that VB-1 has potential for future clinical applications in promoting hair growth. However, the reviewers suggested further investigation and improvements in the manuscript.
