An Update on the Pathophysiology of Female Pattern Hair Loss

March 2011 in “ Hair transplant forum international ”

Mansi Patel, Alfonso Perez, Rodney Sinclair

female pattern hair loss FPHL miniaturization of hair follicles melatonin prolactin pelage growth cycles

TLDR Female pattern hair loss involves hair follicles shrinking, influenced by hormones like melatonin and prolactin.

The document provided an update on the pathophysiology of female pattern hair loss (FPHL). It discussed the selective miniaturization of hair follicles as a key feature of FPHL. The article also explored the roles of melatonin and prolactin in pelage growth cycles, suggesting that these hormones might influence hair growth and loss. The study aimed to enhance the understanding of the biological mechanisms underlying FPHL to improve treatment strategies.

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Research cited in this study

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research Female Patients Complaining About Hair Loss: Documentation of Defective Scalp Hair Dynamics with Contrast-Enhanced Phototrichogram

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community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 828 upvotes 5 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Confused why people are calling PP405 a cure...it never claimed to be able to undo miniaturization or revert vellus back to terminal hairs. It seems to be more of a growth stimulant like minoxidil.

in Research/Science 53 upvotes 2 weeks ago

PP405 is not a cure for hair loss but may reactivate dormant hair follicles, similar to minoxidil. It is unlikely to help with miniaturized or vellus hairs and is still in trial phases, with availability expected around 2030.

community I am a dermatologist with a clinical interest in alopecia. AMA

in Will treatment work for me? 2 years ago

In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

community Got my DHT levels checked. 38 year old female. Still losing hair.

in Female 10 upvotes 8 months ago

A 38-year-old female is experiencing hair loss despite having almost undetectable DHT levels after using dutasteride. Suggestions include checking for PCOS, thyroid issues, adjusting diet, considering the impact of birth control, and trying treatments like tretinoin, redensyl, retinol, and minoxidil with derma stamping.

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A 39-year-old woman noticed hair thinning and found she has an iron deficiency, which may be linked to hair loss. Suggestions included seeing a dermatologist, using spironolactone, and minoxidil.

community Spironolactine Update: 2 months (34, Female)

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A female user's experience using Spironolactone to treat Female Pattern Hair Loss (FPHL) and Androgenic Alopecia, as well as discussing the effectiveness of the drug at different dosages.

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