A Trilayer Dressing with Self-Pumping and pH Monitoring Properties for Promoting Abdominal Wall Defect Repair

    August 2022 in “ Nanomaterials ”
    Jie Hu, Guopu Chen, Gefei Wang
    TLDR The new wound dressing helps heal abdominal wall defects faster by improving the wound environment.
    The study developed a novel trilayer wound dressing using electrospinning, composed of hydrolyzed poly-acrylonitrile (HPAN)/Curcumin (CUR), polyurethane (PU), and polycaprolactone (PCL), to address the challenges of full-thickness abdominal wall defects. The dressing demonstrated biocompatibility, effective directional transport of wound exudation, prevention of reverse penetration, and pH monitoring in vitro. In vivo results indicated that the dressing improved the wound microenvironment, reduced inflammatory factors, promoted angiogenesis, and accelerated abdominal wall repair, suggesting its potential to facilitate the repair of abdominal wall defects.
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