Analyzing the Role of Tofacitinib in Treatment of Alopecia Areata: A Retrospective Analysis from a Tertiary Care Center of North India

January 2023 in “ National Journal of Physiology, Pharmacy and Pharmacology ”

Shalabh Singla, Ranchit Narang, Vinay Shanker, Sharang Gupta, Neha Saraswat, Rajwinder Singh

tofacitinib Janus kinase inhibitor alopecia areata Severity of Alopecia Tool SALT score JAK inhibitor

TLDR Tofacitinib effectively reduced hair loss in alopecia areata patients without adverse effects.

The study evaluated the effectiveness of tofacitinib, a Janus kinase inhibitor, in 17 patients with alopecia areata over a 6-month period at a North Indian tertiary care center. The patients, with a mean age of 27.88 years and a male-to-female ratio of 2.4:1, had been suffering from the condition for an average of 32.29 months. Using the Severity of Alopecia Tool (SALT) score to assess hair loss, the study found a significant reduction in SALT scores (P = 0.0001) after treatment, indicating that tofacitinib was effective. No adverse effects were reported, and all patients completed the study. The research suggests tofacitinib is a promising treatment for alopecia areata, but calls for larger studies to confirm these findings.

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Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 5 months ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community What else is good. Besides the big 3.

in Chat 36 upvotes 6 months ago

Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

community Finasteride and Oral Minoxidil in Turkey - what I’ve found out

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Finasteride is available in Turkey without a prescription, with 1mg tablets costing 800 Turkish lira and 5mg tablets costing 150 lira. Oral minoxidil capsules were found at Cerrahpaşa nur eczanesi, also without a prescription.

community 22F. Should I even bother getting a biopsy? Is there any point?

7 upvotes 9 years ago

A woman who has been experiencing hair loss for several years, and her question of whether there is any benefit to getting a biopsy to check if it's AGA or diffuse alopecia areata when no cure or very effective treatment exists. Treatments such as spironolactone and Minoxidil/finasteride/RU58841 have previously been discussed.

community No hair, don't care! [24/F] :)

61 upvotes 9 years ago

A woman with alopecia universalis shares her positive experience of being bald, finding it freeing and less worrisome. She also discusses her skincare routine using Korean products.

community Female, 27 years old, shedding/ balding despite being on what is considered to be a effective treatment plan for AGA. Considering Dut (oral) . Please help.

in Finasteride/Dutasteride 27 upvotes 5 months ago

A 27-year-old woman with androgenic alopecia is losing hair despite using oral minoxidil and spironolactone, and is considering dutasteride. She is exploring causes like stress and medication side effects, planning tests, and considering treatment changes.

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