Improvement of Recalcitrant Folliculitis Decalvans With Tirzepatide: A Case Report

This case report details a man in his 40s with a long-standing history of recalcitrant folliculitis decalvans (FD), who showed significant improvement in symptoms and hair regrowth after using tirzepatide for weight management. Previously ineffective treatments had failed to alleviate his condition, but tirzepatide, a GLP-1 receptor agonist, led to reduced pain, drainage, and flares, along with notable hair regrowth. These results suggest that tirzepatide may have beneficial anti-inflammatory and immunomodulatory effects for managing FD, indicating the need for further research into the therapeutic potential of GLP-1 agonists for FD and similar inflammatory skin conditions.