The direct inhibitory effect of dutasteride or finasteride on androgen receptor activity is cell line specific
October 2013
in “The Prostate”
TLDR Dutasteride and finasteride affect different cell types differently.
The study found that the inhibitory effect of dutasteride or finasteride on androgen receptor (AR) activity is cell line specific, meaning that the drugs have different effects on different types of cells. The study also found that the AR genotype does not play a significant role in determining the AR antagonistic effect of either drug. The study suggests that further research is needed to understand the role of the direct inhibitory effect of dutasteride or finasteride in reducing prostate cancer.
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research Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor
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Related
research The direct inhibitory effect of dutasteride or finasteride on androgen receptor activity is cell line specific
Dutasteride and finasteride affect different cell types differently.
research The antiandrogenic effect of finasteride against a mutant androgen receptor
Finasteride may improve prostate cancer treatment outcomes.