The composition of cell‐based therapies obtained from point‐of‐care devices/systems which mechanically dissociate lipoaspirate: a scoping review of the literature

This scoping review examined the composition and clinical outcomes of cell-based therapies derived from lipoaspirate using mechanical-only processing devices/systems. Out of 2,895 studies screened, 15 articles met the inclusion criteria, identifying 13 unique devices/systems. The studies reported cell concentration, viability, and immuno-phenotypic analysis, with cell concentration ranging from 0.005 to 21 million cells per milliliter and viability between 60% and 98%. However, only two studies covered all these parameters, and only four investigated clinical outcomes. The review concluded that while devices using filtration and cutting/mincing were most effective in terms of cell concentration, viability, and MSC analysis, it was unclear if these factors led to better clinical outcomes. The lack of standardization and data heterogeneity prevented drawing reliable conclusions about the clinical role of these devices/systems.