Drug–Drug Coamorphous System of Tadalafil and Finasteride for Enhanced Pharmaceutical Performance

December 2025 in “ Molecular Pharmaceutics ”

Nagesh A. Bhale, Avvaru Subha Jahnavi, Rahul Khemchandani, Ganesh Vambhurkar, Rushikesh V. Suradkar, Saurabh Shah, Ramakanta Patel, Nandkumar Doijad, Gananadhamu Samanthula, Saurabh Srivastava, Amol G. Dikundwar

tadalafil finasteride coamorphous system benign prostatic hyperplasia mechanochemical synthesis bioavailability pharmacokinetic properties Cialis Propecia BPH

Studysummary In this study, researchers developed a coamorphous form of tadalafil and finasteride, showing improved solubility and dissolution in vitro, with results successfully translated in vivo in rats. They reported reasonable stability, suggesting this form could serve as a therapeutic alternative to the current marketed combination.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

View this study on pubs.acs.org →

Discuss this study in the Community →

Research cited in this study

3 / 3 results

research Evidence for the Efficacy and Safety of Tadalafil and Finasteride in Combination for the Treatment of Lower Urinary Tract Symptoms and Erectile Dysfunction in Men with Benign Prostatic Hyperplasia

14 citations , May 2016 in “Therapeutic advances in urology”

This review examines the use of tadalafil and finasteride as a combined therapy for BPH, suggesting it may effectively reduce treatment-related sexual adverse events and improve symptom relief.

research Finasteride: Its Impact on Sexual Function and Prostate Cancer

33 citations , January 2009 in “Journal of Cutaneous and Aesthetic Surgery”

This study found no clear evidence that finasteride negatively affects erectile function, though it does cause a reduction in ejaculatory volume and has potential implications for prostate cancer risk.

research Finasteride in the Treatment of Men with Androgenetic Alopecia

581 citations , October 1998 in “Journal of The American Academy of Dermatology”

In male pattern hair loss, this study found that finasteride 1 mg daily significantly slowed hair loss and increased hair growth over two years compared to placebo.