Drug–Drug Coamorphous System of Tadalafil and Finasteride for Enhanced Pharmaceutical Performance

    December 2025 in “ Molecular Pharmaceutics ”
    Nagesh A. Bhale, Avvaru Subha Jahnavi, Rahul Khemchandani, Ganesh Vambhurkar, Rushikesh V. Suradkar, Saurabh Shah, Ramakanta Patel, Nandkumar Doijad, Gananadhamu Samanthula, Saurabh Srivastava, Amol G. Dikundwar
    TLDR Combining tadalafil and finasteride improves their solubility and effectiveness.
    The study presents a novel coamorphous system of tadalafil (TDF) and finasteride (FNS) in a 1:1 molar ratio, aimed at enhancing the pharmaceutical performance of the USFDA-approved combination for treating benign prostatic hyperplasia. This system addresses the low aqueous solubility of both drugs by using mechanochemical synthesis to create a single solid phase. Characterization through various analytical techniques confirmed the formation and stability of the coamorphous phase. In vitro and in vivo studies demonstrated a significant improvement in dissolution and bioavailability compared to the physical mixture. The coamorphous system shows potential as a superior therapeutic alternative due to its improved solubility, dissolution, and pharmacokinetic properties.
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      community Tadafil + finasteride seems to be working better

      in Treatment  23 upvotes 11 months ago
      Tadalafil combined with finasteride seems to improve hair condition for the original poster, who has experienced gradual improvement in hair thinning. Other users discuss the effects of tadalafil on blood flow and its potential benefits for hair growth.

      community Physician here AMA – 30M oral Fin 1-1.25 mg daily

      in Update  47 upvotes 3 years ago
      Hair loss treatments, specifically the use of finasteride, microneedling and potentially oral minoxidil. People discussed their experiences with finasteride, its effects on sexual behaviors, as well as potential solutions such as tadalafil or using other growth factor signal peptides for hope in curing male pattern baldness.

      community So depressed and upset with how much progress I’ve lost

      in Chat  51 upvotes 2 years ago
      A 20-year-old started taking finasteride for hair loss at 18, saw improvement, but developed erectile dysfunction (ED) after taking accutane. Despite stopping both medications, ED persisted, and hair loss worsened. Advice given includes considering tadalafil for ED, resuming finasteride, using minoxidil, and addressing psychological factors through positive thinking and lifestyle changes.

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